Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus

被引：16

作者：

Fox, Jocelyn E. Manning ^{[1
,2
]}

Hajmrle, Catherine ^{[1
,2
]}

MacDonald, Patrick E. ^{[1
,2
]}

机构：

[1] Univ Alberta, Dept Pharmacol, Li Ka Shing Ctr, Edmonton, AB T6G 2E1, Canada

[2] Univ Alberta, Alberta Diabet Inst, Li Ka Shing Ctr, Edmonton, AB T6G 2E1, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2012年 / 90卷 / 06期

基金：

加拿大健康研究院;

关键词：

SUMO; SENP; beta-cell; diabetes; insulin; exocytosis; ion channels; UBIQUITIN-LIKE PROTEIN; INSULIN SECRETORY GRANULES; SENSITIVE K+ CHANNELS; KAPPA-B-ALPHA; TRANSCRIPTIONAL ACTIVATION; DESUMOYLATING ENZYMES; REDOX REGULATION; GENE-EXPRESSION; GLUCOSE; SUMOYLATION;

D O I：

10.1139/Y11-134

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The endocrine pancreas is critically important in the regulation of energy metabolism, with defective insulin secretion from pancreatic islet beta-cells a major contributing factor to the development of type 2 diabetes. Small ubiquitin-like modifier (SUMO) proteins have been demonstrated to covalently modify a wide range of target proteins, mediating a broad range of cellular processes. While the effects of SUMOylation on beta-cell gene transcription have been previously reviewed, recent reports indicate roles for SUMO outside of the nucleus. In this review we shall focus on the reported non-nuclear roles of SUMOylation in the regulation of beta-cells, including SUMOylation as a novel signaling pathway in the acute regulation of insulin secretion.

引用

页码：765 / 770

页数：6

共 63 条

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