Short-Term Oral Nutritional Intervention with Protein and Vitamin D Decreases Falls in Malnourished Older Adults

被引:87
作者
Neelemaat, Floor [1 ,3 ,5 ]
Lips, Paul [2 ,5 ]
Bosmans, Judith E. [4 ,5 ]
Thijs, Abel [3 ]
Seidell, Jaap C. [4 ,5 ]
van Bokhorst-de van der Schueren, Marian A. E. [1 ,3 ,5 ]
机构
[1] Vrije Univ Amsterdam Med Ctr, Dept Nutr & Dietet, NL-1007 MB Amsterdam, Netherlands
[2] Vrije Univ Amsterdam Med Ctr, Endocrinol Sect, NL-1007 MB Amsterdam, Netherlands
[3] Vrije Univ Amsterdam Med Ctr, Dept Internal Med, NL-1007 MB Amsterdam, Netherlands
[4] Vrije Univ Amsterdam, Dept Hlth Sci, Fac Earth & Life Sci, Amsterdam, Netherlands
[5] EMGO Inst Hlth & Care Res, Amsterdam, Netherlands
关键词
falls; elderly patients; nutritional intervention; protein; energy; vitamin D; RCT; BIOELECTRICAL-IMPEDANCE ANALYSIS; RISK-FACTORS; PHYSICAL PERFORMANCE; HOSPITAL DISCHARGE; CONTROLLED-TRIAL; ELDERLY PERSONS; SUPPLEMENTATION; PEOPLE; METAANALYSIS; FRACTURES;
D O I
10.1111/j.1532-5415.2011.03888.x
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
OBJECTIVES: To evaluate the effects of a short-term nutritional intervention with protein and vitamin D on falls in malnourished older adults. DESIGN: Randomized controlled trial. SETTING: From hospital admission until 3 months after discharge. PARTICIPANTS: Malnourished older adults (>= 60) newly admitted to an acute hospital (n = 210). INTERVENTION: Participants were randomized to receive nutritional intervention (energy- and protein-enriched diet, oral nutritional supplements, calcium-vitamin D supplement, telephone counseling by a dietitian) for 3 months after discharge or usual care. MEASUREMENTS: Number of participants who fell, fall incidents, serum 25-hydroxyvitamin D, and dietary intake. Measurements were performed on admission to hospital and 3 months after discharge. RESULTS: Three months after discharge, 10 participants (10%) in the intervention group had fallen at least once, compared with 24 (23%) in the control group (hazard ratio = 0.41, 95% confidence interval (CI) = 0.19-0.86). There were 57 fall incidents (16 in the intervention group; 41 in the control group). A significantly higher intake of energy (280 kcal, 95% CI = 37-524 kcal) and protein (11 g, 95% CI = 1-25 g) and significantly higher serum 25-hydroxyvitamin D levels (10.9 nmol/L, 95% CI = 2.9-18.9 nmol/L) were found in participants in the intervention group than in controls. CONCLUSION: A short-term nutritional intervention consisting of oral nutritional supplements and calcium and vitamin D supplementation and supported by dietetic counseling in malnourished older adults decreases the number of patients who fall and fall incidents. J Am Geriatr Soc 60:691-699, 2012.
引用
收藏
页码:691 / 699
页数:9
相关论文
共 37 条
  • [1] [Anonymous], 1987, DAN MED B, V34, P1
  • [2] Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials
    Bischoff-Ferrari, H. A.
    Dawson-Hughes, B.
    Staehelin, H. B.
    Orav, J. E.
    Stuck, A. E.
    Theiler, R.
    Wong, J. B.
    Egli, A.
    Kiel, D. P.
    Henschkowski, J.
    [J]. BMJ-BRITISH MEDICAL JOURNAL, 2009, 339 : 843
  • [3] Effect of vitamin D on falls - A meta-analysis
    Bischoff-Ferrari, HA
    Dawson-Hughes, B
    Willett, WC
    Staehelin, HB
    Bazemore, MG
    Zee, RY
    Wong, JB
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2004, 291 (16): : 1999 - 2006
  • [4] Vitamin D receptor expression in human muscle tissue decreases with age
    Bischoff-Ferrari, HA
    Borchers, M
    Gudat, F
    Dürmüller, U
    Stähelin, HB
    Dick, W
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (02) : 265 - 269
  • [5] FALLS BY ELDERLY PEOPLE AT HOME - PREVALENCE AND ASSOCIATED FACTORS
    BLAKE, AJ
    MORGAN, K
    BENDALL, MJ
    DALLOSSO, H
    EBRAHIM, SBJ
    ARIE, THD
    FENTEM, PH
    BASSEY, EJ
    [J]. AGE AND AGEING, 1988, 17 (06) : 365 - 372
  • [6] Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: A review of the evidence
    Boonen, S
    Bischoff-Ferrari, HA
    Cooper, C
    Lips, P
    Ljunggren, O
    Meunier, PJ
    Reginster, JY
    [J]. CALCIFIED TISSUE INTERNATIONAL, 2006, 78 (05) : 257 - 270
  • [7] Chevalier S, 2008, J NUTR HEALTH AGING, V12, P721
  • [8] Dutch Nutrition Center, 2001, NED VOED
  • [9] Conjugating the "tenses" of function: Discordance among hypothetical, experimental, and enacted function in older adults
    Glass, TA
    [J]. GERONTOLOGIST, 1998, 38 (01) : 101 - 112
  • [10] Graafmans WC, 1996, AM J EPIDEMIOL, V143, P1129