Influenza Vaccination in Italian Healthcare Workers (2018-2019 Season): Strengths and Weaknesses. Results of a Cohort Study in Two Large Italian Hospitals

被引：17

作者：

Panatto, Donatella ^{[1
,2
]}

Lai, Piero Luigi ^{[1
,2
]}

Mosca, Stefano ^{[2
]}

Lecini, Elvina ^{[1
]}

Orsi, Andrea ^{[1
,2
]}

Signori, Alessio ^{[1
]}

Castaldi, Silvana ^{[3
,4
]}

Pariani, Elena ^{[2
,3
]}

Pellegrinelli, Laura ^{[3
]}

Galli, Cristina ^{[3
]}

Anselmi, Giovanni ^{[3
]}

Icardi, Giancarlo ^{[1
,2
]}

Sticchi, Laura ^{[1
]}

Zangrillo, Francesca ^{[1
]}

Iovine, Mariasilvia ^{[1
]}

Marchini, Francesca ^{[1
]}

Grammatico, Federico ^{[1
]}

Pennati, Beatrice Marina ^{[1
]}

Zacconi, Monica ^{[1
]}

Tassinari, Federico ^{[1
]}

Arcuri, Claudia ^{[1
]}

Canepa, Paola ^{[1
]}

Caligiuri, Patrizia ^{[1
]}

Rappazzo, Emanuela ^{[1
]}

Guarona, Giulia ^{[1
]}

Barisione, Gaia ^{[1
]}

Varesano, Serena ^{[1
]}

Cavazzana, Laura ^{[3
]}

Carnevali, Davide ^{[3
]}

Del Castillo, Gabriele ^{[3
]}

Forni, Giovanni ^{[3
]}

Gandolfi, Cecilia ^{[3
]}

Grimoldi, Ludovico ^{[3
]}

Magnoni, Pietro ^{[3
]}

Mosillo, Marco ^{[3
]}

Pietronigro, Anna ^{[3
]}

Principi, Niccolo ^{[3
]}

Tiwana, Navpreet ^{[3
]}

Battistini, Angela ^{[5
]}

Di Bella, Anna Maria ^{[5
]}

Guglielmi, Barbara ^{[5
]}

Bellina, Dorotea ^{[5
]}

Talamini, Antonella ^{[5
]}

Daturi, Valerio ^{[5
]}

Ziferro, Roberto ^{[5
]}

机构：

[1] Univ Genoa, Dept Hlth Sci, Via Pastore 1, Genoa 16132, Italy

[2] Interuniv Res Ctr Influenza & Other Transmissible, Via Pastore 1, Genoa 16132, Italy

[3] Univ Milan, Dept Biomed Sci Hlth, Via C Pascal 36, Milan 20133, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin Milan, Via F Sforza 28, Milan 20122, Italy

[5] Osped Policlin San Martino IRCCS, Largo R Benzi 10, Genoa 16132, Italy

来源：

VACCINES | 2020年 / 8卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

influenza; influenza vaccination; healthcare workers; laboratory-confirmed influenza; influenza vaccination coverage;

D O I：

10.3390/vaccines8010119

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Annual vaccination is the most effective way to combat influenza. As influenza viruses evolve, seasonal vaccines are updated annually. Within the European project Development of Robust and Innovative Vaccine Effectiveness (DRIVE), a cohort study involving Italian healthcare workers (HCWs) was carried out during the 2018-2019 season. Two aims were defined: to measure influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza cases and to conduct an awareness-raising campaign to increase vaccination coverage. Methods: Each subject enrolled was followed up from enrollment to the end of the study. Each HCW who developed ILI was swabbed for laboratory confirmation of influenza. Influenza viruses were identified by molecular assays. A Cox regression analysis, crude and adjusted for confounding variables, was performed to estimate the IVE. Results: Among the 4483 HCWs enrolled, vaccination coverage was 32.5%, and 308 ILI cases were collected: 23.4% were positive for influenza (54.2% A(H1N1) pdm09; 45.8% A(H3N2)). No influenza B viruses were detected. No overall IVE was observed. Analyzing the subtypes of influenza A viruses, the IVE was estimated as 45% (95% CI: -59 to 81) for A(H1N1) pdm09. Conclusions: Vaccination coverage among HCWs increased. Study difficulties and the circulation of drifted variants of A(H3N2) could partly explain the observed IVE.

引用

页数：13

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