In vitro differentiation potential of mesenchymal stem cells

被引：102

作者：

Gimble, Jeffrey M. ^{[1
]}

Guilak, Farshid ^{[2
]}

Nuttall, Mark E. ^{[3
]}

Sathishkumar, Solomon ^{[4
]}

Vidal, Martin ^{[5
]}

Bunnell, Bruce A. ^{[6
]}

机构：

[1] Pennington Biomed Res Ctr, Stem Cell Biol Lab, Baton Rouge, LA 70808 USA

[2] Duke Univ, Med Ctr, Dept Surg, Div Orthoped Res, Durham, NC 27710 USA

[3] Johnson & Johnson Consumer Prod Inc, Centocor Inc, Philadelphia, PA USA

[4] Christian Med Coll & Hosp, Vellore, Tamil Nadu, India

[5] Louisiana State Univ, Sch Vet Med, Baton Rouge, LA 70803 USA

[6] Tulane Univ, Primate Res Ctr, Covington, LA USA

来源：

TRANSFUSION MEDICINE AND HEMOTHERAPY | 2008年 / 35卷 / 03期

关键词：

adipose-derived stem cells; differentiation; mesenchymal stem cells;

D O I：

10.1159/000124281

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mesenchymal stem cells (MSCs) represent a class of multipotent progenitor cells that have been isolated from multiple tissue sites. Of these, adipose tissue and bone marrow offer advantages in terms of access, abundance, and the extent of their documentation in the literature. This review focuses on the in vitro differentiation capability of cells derived from adult human tissue. Multiple, independent studies have demonstrated that MSCs can commit to mesodermal (adipocyte, chondrocyte, hematopoietic support, myocyte, osteoblast, tenocyte), ectodermal (epithelial, glial, neural), and endodermal (hepatocyte, islet cell) lineages. The limitations and promises of these studies in the context of tissue engineering are discussed.

引用

页码：228 / 238

页数：11

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