In vivo high resolution human corneal imaging using full-field optical coherence tomography

被引：79

作者：

Mazlin, Viacheslav ^{[1
]}

Xiao, Peng ^{[1
]}

Dalimier, Eugenie ^{[2
]}

Grieve, Kate ^{[3
,4
]}

Irsch, Kristina ^{[3
,4
,5
]}

Sahel, Jost-Alain ^{[3
,4
,6
]}

Fink, Mathias ^{[1
]}

Boccara, A. Claude ^{[1
,2
]}

机构：

[1] PSL Res Univ, ESPCI PARIS, Inst Langevin, 1 Rue Jussieu, F-75005 Paris, France

[2] LLTech SAS, 29 Rue Faubourg St Jacques, F-75014 Paris, France

[3] UPMC Sorbonne Univ, Vis Inst, CIC 1423, UMR S 968,INSERM,U968,CNRS,UMR 7210, 17 Rue Moreau, F-75012 Paris, France

[4] Quinze Vingts Natl Eye Hosp, 28 Rue Charenton, F-75012 Paris, France

[5] Johns Hopkins Univ, Wilmer Eye Inst, Lab Ophthalm Instrument Dev, Sch Med, 600 N Wolfe St, Baltimore, MD 21287 USA

[6] Univ Pittsburgh, Dept Ophthalmol, Sch Med, 3550 Terrace St, Pittsburgh, PA 15213 USA

来源：

BIOMEDICAL OPTICS EXPRESS | 2018年 / 9卷 / 02期

基金：

欧洲研究理事会;

关键词：

SWEPT SOURCE OCT; ANTERIOR SEGMENT; HIGH-SPEED; CONFOCAL MICROSCOPY; ULTRAHIGH-RESOLUTION; OCULAR SURFACE; HUMAN DONOR; EYE; VISUALIZATION; BLINDNESS;

D O I：

10.1364/BOE.9.000557

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We present the first full-field optical coherence tomography (FFOCT) device capable of in vivo imaging of the human cornea. We obtained images of the epithelial structures, Bowman's layer, sub-basal nerve plexus (SNP), anterior and posterior stromal keratocytes, stromal nerves, Descemet's membrane and endothelial cells with visible nuclei. Images were acquired with a high lateral resolution of 1.7 mu m and relatively large field-of-view of 1.26 mm x 1.26 mm - a combination, which, to the best of our knowledge, has not been possible with other in vivo human eye imaging methods. The latter together with a contactless operation, make FFOCT a promising candidate for becoming a new tool in ophthalmic diagnostics. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：557 / 568

页数：12

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