Quantitative 31P-NMR spectroscopy for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium

被引:9
作者
Jiang, Haipeng [1 ]
Chen, Hong [2 ]
Cai, Nian [2 ]
Zou, Jing [1 ]
Ju, Xiulian [2 ]
机构
[1] Wuhan Inst Technol, Ctr Anal & Test, Wuhan 430073, Peoples R China
[2] Wuhan Inst Technol, Sch Chem Engn & Pharm, Wuhan 430073, Peoples R China
关键词
NMR; quantitative P-31-NMR; coaxial insert; fosfomycin; NUCLEAR-MAGNETIC-RESONANCE; NMR-SPECTROSCOPY; ALKYLPHOSPHONIC ACIDS; ELECTROPHORESIS; CHROMATOGRAPHY; VALIDATION; SAMPLES; AGENTS; DRUG;
D O I
10.1002/mrc.4224
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A quantitative P-31-NMR method for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium has been developed. In this method, coaxial inserts containing trimethyl phosphate are used as external standard. The method is convenient and robust, and gives both high accuracy and precision. It is shown that an accurate determination is possible using different probes and coaxial inserts. Copyright (c) 2015 John Wiley & Sons, Ltd.
引用
收藏
页码:454 / 459
页数:6
相关论文
共 22 条
[1]   31P NMR spectroscopy in the quality control and authentication of extra-virgin olive oil:: A review of recent progress [J].
Dais, Photis ;
Spyros, Apostolos .
MAGNETIC RESONANCE IN CHEMISTRY, 2007, 45 (05) :367-377
[2]   Fosfomycin: Use beyond urinary tract and gastrointestinal infections [J].
Falagas, Matthew E. ;
Giannopoulou, Konstantina P. ;
Kokolakis, George N. ;
Rafailidis, Petros I. .
CLINICAL INFECTIOUS DISEASES, 2008, 46 (07) :1069-1077
[3]   QUANTITATIVE-ANALYSIS OF SHORT-CHAIN PHOSPHATES BY P-31 NUCLEAR-MAGNETIC-RESONANCE AND INTERLABORATORY COMPARISON WITH INFRARED AND CHROMATOGRAPHIC METHODS [J].
GARD, DR ;
BURQUIN, JC ;
GARD, JK .
ANALYTICAL CHEMISTRY, 1992, 64 (05) :557-561
[4]   QUANTITATIVE ANALYSIS BY NUCLEAR MAGNETIC RESONANCE SPECTROMETRY USING PRECISION COAXIAL TUBING [J].
HATADA, K ;
TERAWAKI, Y ;
OKUDA, H ;
NAGATA, K ;
YUKI, H .
ANALYTICAL CHEMISTRY, 1969, 41 (11) :1518-&
[5]   Quantitative NMR Spectroscopy using coaxial inserts containing a reference standard: Purity determinations for military nerve agents [J].
Henderson, TJ .
ANALYTICAL CHEMISTRY, 2002, 74 (01) :191-198
[6]   Determination of fosfomycin in chicken plasma samples by gas chromatography:: Application to pharmacokinetic studies [J].
Hernández, E ;
Loste, A ;
Bregante, MA ;
García, MA ;
Solans, C .
CHROMATOGRAPHIA, 2001, 54 (5-6) :365-368
[7]   Quantitative NMR spectroscopy - Applications in drug analysis [J].
Holzgrabe, U ;
Deubner, R ;
Schollmayer, C ;
Waibel, B .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 38 (05) :806-812
[8]   Quantitative NMR spectroscopy in pharmaceutical applications [J].
Holzgrabe, Ulrike .
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 2010, 57 (02) :229-240
[9]  
Kestle D G, 1969, Antimicrob Agents Chemother (Bethesda), V9, P332
[10]   Methylphosphonic acid as a 31P-NMR standard for the quantitative determination of phosphorus in carbonated beverages [J].
Kollo, Marek ;
Kudrjasova, Marina ;
Kulp, Maria ;
Aav, Riina .
ANALYTICAL METHODS, 2013, 5 (16) :4005-4009