In vivo flow speed measurement of capillaries by photoacoustic correlation spectroscopy

被引：65

作者：

Chen, Sung-Liang ^{[1
]}

Xie, Zhixing ^{[2
]}

Carson, Paul L. ^{[2
]}

Wang, Xueding ^{[2
]}

Guo, L. Jay ^{[1
]}

机构：

[1] Univ Michigan, Dept Elect Engn & Comp Sci, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

OPTICS LETTERS | 2011年 / 36卷 / 20期

基金：

美国国家卫生研究院;

关键词：

BLOOD-FLOW; VELOCITY; TRANSPORT;

D O I：

10.1364/OL.36.004017

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We recently proposed photoacoustic correlation spectroscopy (PACS) and demonstrated a proof-of-concept experiment. Here we use the technique for in vivo flow speed measurement in capillaries in a chick embryo model. The photoacoustic microscopy system is used to render high spatial resolution and high sensitivity, enabling sufficient signals from single red blood cells. The probe beam size is calibrated by a blood-mimicking phantom. The results indicate the feasibility of using PACS to study flow speeds in capillaries. (C) 2011 Optical Society of America

引用

页码：4017 / 4019

页数：3

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