Synthesis of vitamin D in skin after burns

被引:62
|
作者
Klein, GL
Chen, TC
Holick, MF
Langman, CB
Price, H
Celis, MM
Herndon, DN
机构
[1] Univ Texas, Med Branch, Dept Paediat, Galveston, TX 77550 USA
[2] Univ Texas, Med Branch, Dept Surg, Galveston, TX 77550 USA
[3] Shriners Burns Hosp, Galveston, TX USA
[4] Boston Univ, Med Ctr, Dept Med, Boston, MA USA
[5] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA
来源
LANCET | 2004年 / 363卷 / 9405期
关键词
D O I
10.1016/S0140-6736(03)15388-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.
引用
收藏
页码:291 / 292
页数:2
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