Synthesis of vitamin D in skin after burns

被引：63

作者：

Klein, GL

Chen, TC

Holick, MF

Langman, CB

Price, H

Celis, MM

Herndon, DN

机构：

[1] Univ Texas, Med Branch, Dept Paediat, Galveston, TX 77550 USA

[2] Univ Texas, Med Branch, Dept Surg, Galveston, TX 77550 USA

[3] Shriners Burns Hosp, Galveston, TX USA

[4] Boston Univ, Med Ctr, Dept Med, Boston, MA USA

[5] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Chicago, IL 60614 USA

来源：

LANCET | 2004年 / 363卷 / 9405期

关键词：

D O I：

10.1016/S0140-6736(03)15388-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Severe burn injury is associated with vitamin D deficiency, low bone turnover, and abnormalities in calcium homoeostasis. Patients do not routinely receive vitamin D supplementation and sun exposure is currently not controlled. By analysis of skin biopsy samples for vitamin D3 precursors after exposure to ultraviolet B light we found that the conversion of 7-dehydrocholesterol to previtamin D3 was reduced in children a mean of 14 months after the burn. Low serum 25-hydroxyvitamin D concentrations were also found. We conclude that vitamin D supplementation is necessary after burn injury.

引用

页码：291 / 292

页数：2

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