Virtual Special Issue: Epigenetics 2022

被引：0

作者：

Aldrich, Courtney C.

Calderon, Felix

Conway, Stuart J.

He, Chuan

Hooker, Jacob M.

Huryn, Donna M.

Lindsley, Craig W.

Liotta, Dennis C.

Muller, Christa E.

机构：

来源：

ACS INFECTIOUS DISEASES | 2022年 / 8卷 / 10期

关键词：

EXTRA-TERMINAL DOMAIN; BROMODOMAIN; INHIBITORS; DISCOVERY; IDENTIFICATION; AFFINITY; LIGANDS; DESIGN;

D O I：

10.1021/acsinfecdis.2c00434

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Without question, epigenetics is one of the fastest growing, and most impactful, fields in chemical biology, neuroscience, medicinal chemistry, and drug discovery today. Recognizing the importance of this area, in 2020 we invited submissions for a virtual special issue on this topic hosted by Pharmacology & Translational Science, and the Journal of Medicinal Chemistry. We are now delighted to present the Epigenetics 2022 virtual special issue. Below, content from each of the journals involved in this collection of papers is highlighted.

引用

页码：1975 / 1980

页数：6

共 74 条

[1] Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies [J].

Alford, Joshua S. ;

Lampe, John W. ;

Brach, Dorothy ;

Chesworth, Richard ;

Cosmopoulos, Kat ;

Duncan, Kenneth W. ;

Eckley, Sean T. ;

Raimondi, Alejandra ;

V. Riera, Thomas ;

Shook, Brian ;

Tang, Cuyue ;

Totman, Jennifer ;

Farrow, Neil A. .

ACS MEDICINAL CHEMISTRY LETTERS, 2022, 13 (07) :1137-1143

[2] Diverse, Potent, and Efficacious Inhibitors That Target the EED Subunit of the Polycomb Repressive Complex 2 Methyltransferase [J].

Bagal, Sharan K. ;

Gregson, Clare ;

O' Donovan, Daniel H. ;

Pike, Kurt G. ;

Bloecher, Andrew ;

Barton, Peter ;

Borodovsky, Alexandra ;

Code, Erin ;

Fillery, Shaun M. ;

Hsu, Jessie Hao-Ru ;

Kawatkar, Sameer P. ;

Li, Chengzhi ;

Longmire, David ;

Nai, Youfeng ;

Nash, Samuel C. ;

Pike, Andrew ;

Robinson, James ;

Read, Jon A. ;

Rawlins, Phillip B. ;

Shen, Minhui ;

Tang, Jia ;

Wang, Peng ;

Woods, Haley ;

Williamson, Beth .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (23) :17146-17183

[3] Design, Synthesis, and Evaluation of Thienodiazepine Derivatives as Positron Emission Tomography Imaging Probes for Bromodomain and Extra-Terminal Domain Family Proteins [J].

Bai, Ping ;

Lan, Yu ;

Patnaik, Debasis ;

Wang, Hao ;

Liu, Yan ;

Chen, Zude ;

Yuan, Gengyang ;

Afshar, Sepideh ;

Striar, Robin ;

Zagaroli, Julia S. ;

Tocci, Darcy R. ;

Langan, Amelia G. ;

Haggarty, Stephen J. ;

Wang, Changning .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (19) :14745-14756

[4] Chasing a Breath of Fresh Air in Cystic Fibrosis (CF): Therapeutic Potential of Selective HDAC6 Inhibitors to Tackle Multiple Pathways in CF Pathophysiology [J].

Barone, Simona ;

Cassese, Emilia ;

Alfano, Antonella Ilenia ;

Brindisi, Margherita ;

Summa, Vincenzo .

JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (04) :3080-3097

[5] Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain [J].

Brand, Michael ;

Clayton, James ;

Moroglu, Mustafa ;

Schiedel, Matthias ;

Picaud, Sarah ;

Bluck, Joseph P. ;

Skwarska, Anna ;

Bolland, Hannah ;

Chan, Anthony K. N. ;

Laurin, Corentine M. C. ;

Scorah, Amy R. ;

See, Larissa ;

Rooney, Timothy P. C. ;

Andrews, Katrina H. ;

Fedorov, Oleg ;

Perell, Gabriella ;

Kalra, Prakriti ;

Vinh, Kayla B. ;

Cortopassi, Wilian A. ;

Heitel, Pascal ;

Christensen, Kirsten E. ;

Cooper, Richard, I ;

Paton, Robert S. ;

Pomerantz, William C. K. ;

Biggin, Philip C. ;

Hammond, Ester M. ;

Filippakopoulos, Panagis ;

Conway, Stuart J. .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (14) :10102-10123

[6] Discovery of DDO-2213 as a Potent and Orally Bioavailable Inhibitor of the WDR5-Mixed Lineage Leukemia 1 Protein-Protein Interaction for the Treatment of MLL Fusion Leukemia [J].

Chen, Weilin ;

Chen, Xin ;

Li, Dongdong ;

Zhou, Jianrui ;

Jiang, Zhengyu ;

You, Qidong ;

Guo, Xiaoke .

JOURNAL OF MEDICINAL CHEMISTRY, 2021, 64 (12) :8221-8245

[7] Antiproliferation and Antiencystation Effect of Class II Histone Deacetylase Inhibitors on Acanthamoeba castellanii [J].

Chu, Ki-Back ;

Lee, Hae-Ahm ;

Pflieger, Marc ;

Fischer, Fabian ;

Asfaha, Yodita ;

Avelar, Leandro A. Alves ;

Skerhut, Alexander ;

Kassack, Matthias U. ;

Hansen, Finn K. ;

Schoeler, Andrea ;

Kurz, Thomas ;

Kim, Min-Jeong ;

Moon, Eun-Kyung ;

Quan, Fu-Shi .

ACS INFECTIOUS DISEASES, 2022, 8 (02) :271-279

[8] Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease [J].

Cobos, Samantha N. ;

Torrente, Mariana P. .

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE, 2022, 5 (02) :134-137

[9] Cyclic Tetrapeptide HDAC Inhibitors with Improved Plasmodium falciparum Selectivity and Killing Profile [J].

Collins, Jennifer E. ;

Lee, Jin Woo ;

Bohmer, Monica J. ;

Welden, Joshua D. ;

Arshadi, Arash K. ;

Du, Lin ;

Cichewicz, Robert H. ;

Chakrabarti, Debopam .

ACS INFECTIOUS DISEASES, 2021, 7 (10) :2889-2903

[10] A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes [J].

Cui, Huarui ;

Divakaran, Anand ;

Hoell, Zachariah J. ;

Ellingson, Mikael O. ;

Scholtz, Cole R. ;

Zahid, Huda ;

Johnson, Jorden A. ;

Griffith, Elizabeth C. ;

Gee, Clifford T. ;

Lee, Amani L. ;

Khanal, Shalil ;

Shi, Ke ;

Aihara, Hideki ;

Shah, Vijay H. ;

Lee, Richard E. ;

Harki, Daniel A. ;

Pomerantz, William C. K. .

JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (03) :2342-2360

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