A self-assembled peptide nucleic acid-microRNA nanocomplex for dual modulation of cancer-related microRNAs

被引：13
作者：
Wang, Xingxing [1 ]
Xiao, Xiao [1 ]
Zhang, Bingsen [1 ]
Li, Jinbo [1 ]
Zhang, Yan [1 ]
机构：
[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 14期
基金：
中国国家自然科学基金;
关键词：
SIRNA DELIVERY; CHEMISTRY; NANOPARTICLES; REPRESSION; INFECTION; RNA; PNA;
D O I：
10.1039/c9cc00002j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Here, we report a new strategy for the construction of a peptide nucleic acid-microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive microRNAs in target cancer cells.
引用
收藏
页码：2106 / 2109
页数：4
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