A self-assembled peptide nucleic acid-microRNA nanocomplex for dual modulation of cancer-related microRNAs

被引：13

作者：

Wang, Xingxing ^{[1
]}

Xiao, Xiao ^{[1
]}

Zhang, Bingsen ^{[1
]}

Li, Jinbo ^{[1
]}

Zhang, Yan ^{[1
]}

机构：

[1] Nanjing Univ, State Key Lab Analyt Chem Life Sci, Jiangsu Key Lab Adv Organ Mat, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 14期

基金：

中国国家自然科学基金;

关键词：

SIRNA DELIVERY; CHEMISTRY; NANOPARTICLES; REPRESSION; INFECTION; RNA; PNA;

D O I：

10.1039/c9cc00002j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here, we report a new strategy for the construction of a peptide nucleic acid-microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive microRNAs in target cancer cells.

引用

页码：2106 / 2109

页数：4

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