Stability and properties of Z-DNA containing artificial nucleobase 2′-O-methyl-8-methyl guanosine

被引：4

作者：

Balasubramaniyam, Thananjeyan ^{[1
]}

Ishizuka, Takumi ^{[1
]}

Xu, Yan ^{[1
]}

机构：

[1] Univ Miyazaki, Div Chem, Dept Med Sci, Fac Med, 5200 Kihara, Kiyotake, Miyazaki 8891692, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2019年 / 27卷 / 02期

关键词：

Z-DNA oligonucleotide; Artificial nucleobase; Photochemical reaction; Interaction of protein and Z-DNA; Circular dichroism; Z-ALPHA DOMAIN; B-Z TRANSITION; PROTEIN-KINASE; CRYSTAL-STRUCTURE; BINDING DOMAIN; 1ST EVIDENCE; CONFORMATION; DEOXYRIBOSE; EXPRESSION; INDUCE;

D O I：

10.1016/j.bmc.2018.12.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We synthesized several DNA oligonucleotides containing one or several 2'-O-methyl-8-methyl guanosine (m(8)Gm) and demonstrated that these oligonucleotides not only stabilize the Z-DNA with a wide range of sequences under low salt conditions but also possess high thermal stability. Using artificial nucleobase-containing oligonucleotides, we studied the interaction of the Z alpha domain with Z-DNA. Furthermore, we showed that the m(8)Gm-contained oligonucleotides allow to study the photochemical reaction of Z-DNA.

引用

页码：364 / 369

页数：6

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