Role of amyloid β in the induction of lipolysis and secretion of adipokines from human adipose tissue

被引：12

作者：

Wan, Zhongxiao ^{[1
]}

Mah, Dorrian ^{[1
]}

Simtchouk, Svetlana ^{[1
]}

Kluftinger, Andreas ^{[2
]}

Little, Jonathan P. ^{[1
]}

机构：

[1] Univ British Columbia Okanagan, Sch Hlth & Exercise Sci, Kelowna, BC, Canada

[2] Kelowna Gen Hosp, Dept Surg, Kelowna, BC, Canada

来源：

ADIPOCYTE | 2015年 / 4卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amyloid-beta peptide; lipolysis; inflammation; adipose tissue; adipokine; TUMOR-NECROSIS-FACTOR; HORMONE-SENSITIVE LIPASE; INSULIN-RESISTANCE; IN-VITRO; PROTEIN-KINASE; 3T3-L1; ADIPOCYTES; INTERLEUKIN-6; CELLS; EXPRESSION; OBESITY;

D O I：

10.4161/21623945.2014.985020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloid-beta (A beta) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and A beta peptides are expressed in adipose tissue, however it is currently unclear whether A beta can affect the key functions of adipose tissue. We aimed to explore whether A beta affected lipolysis and adipokine secretion in cultured human adipose tissue. We found that A beta(25-35), which contains the main functional domain of the A beta, stimulated lipolysis via PKA and ERK1/2-dependent pathways and that A beta(25-35) induced leptin and IL-6 secretion. It is concluded that A beta peptide exerts functional effects on adipose tissue that may lead to increased release of free fatty acids and pro-inflammatory adipokines.

引用

页码：212 / 216

页数：5

共 50 条

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