Role of amyloid β in the induction of lipolysis and secretion of adipokines from human adipose tissue

被引：13

作者：

Wan, Zhongxiao ^{[1
]}

Mah, Dorrian ^{[1
]}

Simtchouk, Svetlana ^{[1
]}

Kluftinger, Andreas ^{[2
]}

Little, Jonathan P. ^{[1
]}

机构：

[1] Univ British Columbia Okanagan, Sch Hlth & Exercise Sci, Kelowna, BC, Canada

[2] Kelowna Gen Hosp, Dept Surg, Kelowna, BC, Canada

来源：

ADIPOCYTE | 2015年 / 4卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amyloid-beta peptide; lipolysis; inflammation; adipose tissue; adipokine; TUMOR-NECROSIS-FACTOR; HORMONE-SENSITIVE LIPASE; INSULIN-RESISTANCE; IN-VITRO; PROTEIN-KINASE; 3T3-L1; ADIPOCYTES; INTERLEUKIN-6; CELLS; EXPRESSION; OBESITY;

D O I：

10.4161/21623945.2014.985020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloid-beta (A beta) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and A beta peptides are expressed in adipose tissue, however it is currently unclear whether A beta can affect the key functions of adipose tissue. We aimed to explore whether A beta affected lipolysis and adipokine secretion in cultured human adipose tissue. We found that A beta(25-35), which contains the main functional domain of the A beta, stimulated lipolysis via PKA and ERK1/2-dependent pathways and that A beta(25-35) induced leptin and IL-6 secretion. It is concluded that A beta peptide exerts functional effects on adipose tissue that may lead to increased release of free fatty acids and pro-inflammatory adipokines.

引用

页码：212 / 216

页数：5

共 34 条

[21] Conformations and Biological Activities of Amyloid Beta Peptide 25-35 [J].

Millucci, L. ;

Ghezzi, L. ;

Bernardini, G. ;

Santucci, A. .

CURRENT PROTEIN & PEPTIDE SCIENCE, 2010, 11 (01) :54-67

[22]

Montecucco F, 2013, MEDIAT INFLAMM, V2013

[23] Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype [J].

Ohashi, Koji ;

Parker, Jennifer L. ;

Ouchi, Noriyuki ;

Higuchi, Akiko ;

Vita, Joseph A. ;

Gokce, Noyan ;

Pedersen, Anette Amstrup ;

Kalthoff, Christoph ;

Tullin, Soren ;

Sams, Anette ;

Summer, Ross ;

Walsh, Kenneth .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (09) :6153-6160

[24] Amyloid Precursor Protein and Proinflammatory Changes Are Regulated in Brain and Adipose Tissue in a Murine Model of High Fat Diet-Induced Obesity [J].

Puig, Kendra L. ;

Floden, Angela M. ;

Adhikari, Ramchandra ;

Golovko, Mikhail Y. ;

Combs, Colin K. .

PLOS ONE, 2012, 7 (01)

[25] CHF5074 Protects SH-SY5Y Human Neuronal-like Cells from Amyloid-beta 25-35 and Tumor Necrosis Factor Related Apoptosis Inducing Ligand Toxicity In Vitro [J].

Ronsisvalle, Nicole ;

Di Benedetto, Giulia ;

Parenti, Carmela ;

Amoroso, Salvatore ;

Bernardini, Renato ;

Cantarella, Giuseppina .

CURRENT ALZHEIMER RESEARCH, 2014, 11 (07) :714-724

[26] Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-α, overexpressed in human fat cells from insulin-resistant subjects [J].

Rotter, V ;

Nagaev, I ;

Smith, U .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (46) :45777-45784

[27] A NOVEL SERUM-PROTEIN SIMILAR TO C1Q, PRODUCED EXCLUSIVELY IN ADIPOCYTES [J].

SCHERER, PE ;

WILLIAMS, S ;

FOGLIANO, M ;

BALDINI, G ;

LODISH, HF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (45) :26746-26749

[28] Amyloid Precursor Protein Expression Is induced by Tumor Necrosis Factor α in 3T3-L1 Adipocytes [J].

Sommer, Grit ;

Kralisch, Susan ;

Lipfert, Jana ;

Weise, Sebastian ;

Krause, Kerstin ;

Jessnitzer, Beate ;

Loessner, Ulrike ;

Blueher, Matthias ;

Stumvoll, Michael ;

Fasshauer, Mathias .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 108 (06) :1418-1422

[29] Functional studies on native and mutated forms of perilipins - A role in protein kinase A-mediated lipolysis of triacylglycerols in Chinese hamster ovary cells [J].

Tansey, JT ;

Huml, AM ;

Vogt, R ;

Davis, KE ;

Jones, JM ;

Fraser, KA ;

Brasaemle, DL ;

Kimmel, AR ;

Londos, C .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (10) :8401-8406

[30] Epinephrine-mediated regulation of PDK4 mRNA in rat adipose tissue [J].

Wan, Zhongxiao ;

Thrush, A. Brianne ;

Legare, Melanie ;

Frier, Bruce C. ;

Sutherland, Lindsey N. ;

Williams, Deon B. ;

Wright, David C. .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 299 (05) :C1162-C1170

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