Role of amyloid β in the induction of lipolysis and secretion of adipokines from human adipose tissue

被引：12

作者：

Wan, Zhongxiao ^{[1
]}

Mah, Dorrian ^{[1
]}

Simtchouk, Svetlana ^{[1
]}

Kluftinger, Andreas ^{[2
]}

Little, Jonathan P. ^{[1
]}

机构：

[1] Univ British Columbia Okanagan, Sch Hlth & Exercise Sci, Kelowna, BC, Canada

[2] Kelowna Gen Hosp, Dept Surg, Kelowna, BC, Canada

来源：

ADIPOCYTE | 2015年 / 4卷 / 03期

基金：

加拿大自然科学与工程研究理事会;

关键词：

amyloid-beta peptide; lipolysis; inflammation; adipose tissue; adipokine; TUMOR-NECROSIS-FACTOR; HORMONE-SENSITIVE LIPASE; INSULIN-RESISTANCE; IN-VITRO; PROTEIN-KINASE; 3T3-L1; ADIPOCYTES; INTERLEUKIN-6; CELLS; EXPRESSION; OBESITY;

D O I：

10.4161/21623945.2014.985020

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Amyloid-beta (A beta) peptide, which is generated from proteolytic cleavage of amyloid precursor protein (APP), is a key molecule involved in the pathology of Alzheimer disease. Both APP and A beta peptides are expressed in adipose tissue, however it is currently unclear whether A beta can affect the key functions of adipose tissue. We aimed to explore whether A beta affected lipolysis and adipokine secretion in cultured human adipose tissue. We found that A beta(25-35), which contains the main functional domain of the A beta, stimulated lipolysis via PKA and ERK1/2-dependent pathways and that A beta(25-35) induced leptin and IL-6 secretion. It is concluded that A beta peptide exerts functional effects on adipose tissue that may lead to increased release of free fatty acids and pro-inflammatory adipokines.

引用

页码：212 / 216

页数：5

共 34 条

[1] Triacylglycerol metabolism in adipose tissue
Ahmadian, Mayam
Duncan, Robin E.
Jaworski, Kathy
Sarkadi-Nagy, Eszter
Sul, Hei Sook
[J]. FUTURE LIPIDOLOGY, 2007, 2 (02): : 229 - 237
[2] PD-098059 IS A SPECIFIC INHIBITOR OF THE ACTIVATION OF MITOGEN-ACTIVATED PROTEIN-KINASE KINASE IN-VITRO AND IN-VIVO
ALESSI, DR
CUENDA, A
COHEN, P
DUDLEY, DT
SALTIEL, AR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (46) : 27489 - 27494
[3] β-amyloid peptide25-35 depresses excitatory synaptic transmission in the rat basolateral amygdala "in vitro"
Ashenafi, S
Fuente, A
Criado, JM
Riolobos, AS
Heredia, M
Yajeya, J
[J]. NEUROBIOLOGY OF AGING, 2005, 26 (04) : 419 - 428
[4] Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro
Bastard, JP
Maachi, M
Van Nhieu, JT
Jardel, C
Bruckert, E
Grimaldi, A
Robert, JJ
Capeau, J
Hainque, B
[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2002, 87 (05) : 2084 - 2089
[5] Serum immunoreactive leptin concentrations in normal-weight and obese humans
Considine, RV
Sinha, MK
Heiman, ML
Kriauciunas, A
Stephens, TW
Nyce, MR
Ohannesian, JP
Marco, CC
McKee, LJ
Bauer, TL
Caro, JF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (05) : 292 - 295
[6] The secretases: enzymes with therapeutic potential in Alzheimer disease
De Strooper, Bart
Vassar, Robert
Golde, Todd
[J]. NATURE REVIEWS NEUROLOGY, 2010, 6 (02) : 99 - 107
[7] MECHANISM OF HORMONE-STIMULATED LIPOLYSIS IN ADIPOCYTES - TRANSLOCATION OF HORMONE-SENSITIVE LIPASE TO THE LIPID STORAGE DROPLET
EGAN, JJ
GREENBERG, AS
CHANG, MK
WEK, SA
MOOS, MC
LONDOS, C
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (18) : 8537 - 8541
[8] Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89 - Structural implications for selectivity
Engh, RA
Girod, A
Kinzel, V
Huber, R
Bossemeyer, D
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) : 26157 - 26164
[9] Adiponectin gene expression and secretion is inhibited by interleukin-6 in 3T3-L1 adipocytes
Fasshauer, M
Kralisch, S
Klier, M
Lossner, U
Bluher, M
Klein, J
Paschke, R
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (04) : 1045 - 1050
[10] Regulation of leptin production in humans
Fried, SK
Ricci, MR
Russell, CD
Laferrère, B
[J]. JOURNAL OF NUTRITION, 2000, 130 (12) : 3127S - 3131S

← 1 2 3 4 →