Hair Graying Regulators Beyond Hair Follicle

被引:6
作者
Chen, Jing [1 ,2 ]
Zheng, Yixin [2 ]
Hu, Chen [3 ]
Jin, Xuexiao [4 ,5 ]
Chen, Xiaoping [4 ,5 ]
Xiao, Ying [6 ]
Wang, Chaochen [1 ,2 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Breast Surg, Hangzhou, Peoples R China
[2] Zhejiang Univ, Zhejiang Univ Univ Edinburgh Inst, Haining, Peoples R China
[3] Zhejiang Univ, Sch Med, Hangzhou, Peoples R China
[4] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Inst Immunol, Hangzhou, Peoples R China
[5] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Rheumatol, Hangzhou, Peoples R China
[6] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Cent Lab Biomed Res Ctr, Hangzhou, Peoples R China
基金
中国国家自然科学基金;
关键词
hair graying; melanocyte stem cells; nerves; adipocytes; immune cells; ADIPOSE-TISSUE; STEM-CELLS; SKIN; MELANOCYTES; GROWTH; EXPRESSION; PIGMENTATION; INNERVATION; DIFFERENTIATION; FIBROBLASTS;
D O I
10.3389/fphys.2022.839859
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Hair graying is an interesting physiological alteration associated with aging and certain diseases. The occurrence is due to depigmentation of the hair caused by depletion and dysfunction of melanocyte stem cells (MeSCs). However, what causes the depletion and dysfunction of MeSCs remains unclear. MeSCs reside in the hair follicle bulge which provides the appropriate niche for the homeostasis of various stem cells within hair follicle including MeSCs. In addition to local signaling from the cells composed of hair follicle, emerging evidences have shown that nerves, adipocytes and immune cells outside of hair follicle per se also play important roles in the regulation of MeSCs. Here, we review the recent studies on different cells in the MeSCs microenvironment beyond the hair follicle per se, discuss their function in regulating hair graying and potentially novel treatments of hair graying.
引用
收藏
页数:7
相关论文
共 73 条
  • [1] Evaluation of oxidative stress and psychoemotional status in premature hair graying
    Acer, Ersoy
    Erdogan, Hilal Kaya
    Kocaturk, Evin
    Saracoglu, Zeynep Nurhan
    Alatas, Ozkan
    Bilgin, Muzaffer
    [J]. JOURNAL OF COSMETIC DERMATOLOGY, 2020, 19 (12) : 3403 - 3407
  • [2] Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin
    Adameyko, Igor
    Lallemend, Francois
    Aquino, Jorge B.
    Pereira, Jorge A.
    Topilko, Piotr
    Mueller, Thomas
    Fritz, Nicolas
    Beljajeva, Anna
    Mochii, Makoto
    Liste, Isabel
    Usoskin, Dmitry
    Suter, Ueli
    Birchmeier, Carmen
    Ernfors, Patrik
    [J]. CELL, 2009, 139 (02) : 366 - 379
  • [3] Dermal white adipose tissue: a new component of the thermogenic response
    Alexander, Caroline M.
    Kasza, Ildiko
    Yen, C-L. Eric
    Reeder, Scott B.
    Hernando, Diego
    Gallo, Richard L.
    Jahoda, Colin A. B.
    Horsley, Valerie
    MacDougald, Ormond A.
    [J]. JOURNAL OF LIPID RESEARCH, 2015, 56 (11) : 2061 - 2069
  • [4] Asz-Sigall Daniel, 2023, J Am Acad Dermatol, V89, P758, DOI 10.1016/j.jaad.2018.12.047
  • [5] Hair follicle immune privilege and its collapse in alopecia areata
    Bertolini, Marta
    McElwee, Kevin
    Gilhar, Amos
    Bulfone-Paus, Silvia
    Paus, Ralf
    [J]. EXPERIMENTAL DERMATOLOGY, 2020, 29 (08) : 703 - 725
  • [6] Botchkarev VA, 1997, J COMP NEUROL, V386, P379, DOI 10.1002/(SICI)1096-9861(19970929)386:3<379::AID-CNE4>3.0.CO
  • [7] 2-Z
  • [8] Hair cycle-dependent changes in adrenergic skin innervation, and hair growth modulation by adrenergic drugs
    Botchkarev, VA
    Peters, EMJ
    Botchkareva, NV
    Maurer, M
    Paus, R
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (06) : 878 - 887
  • [9] Nerve-Derived Sonic Hedgehog Defines a Niche for Hair Follicle Stem Cells Capable of Becoming Epidermal Stem Cells
    Brownell, Isaac
    Guevara, Elizabeth
    Bai, C. Brian
    Loomis, Cynthia A.
    Joyner, Alexandra L.
    [J]. CELL STEM CELL, 2011, 8 (05) : 552 - 565
  • [10] Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells
    Castellana, Donatello
    Paus, Ralf
    Perez-Moreno, Mirna
    [J]. PLOS BIOLOGY, 2014, 12 (12)