Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression

被引：107

作者：

Bellivier, F

Henry, C

Szöke, A

Schürhoff, F

Nosten-Bertrand, M

Feingold, J

Launay, JM

Leboyer, M

Laplanche, JL

机构：

[1] Hop La Pitie Salpetriere, CNRS UMR 7593 Pavillon Clerambault, Lab Rech Personnalites & Conduites Adaptat, F-75013 Paris, France

[2] Hop Charles Perrens, Serv Psychiat Adulte, Bordeaux, France

[3] Hop La Pitie Salpetriere, Lab Genet Neurotransmiss, CNRS UMR 9923, Paris, France

[4] Univ Jussieu, INSERM U155, Lab Genet Epidemiol, Paris, France

[5] Hop Lariboisiere, Cent Biochim Lab, Assistance Publ Hop Paris, F-75475 Paris, France

[6] Assistance Publ Hop Paris, Serv Psychiat Adulte, Paris, France

来源：

NEUROSCIENCE LETTERS | 1998年 / 255卷 / 03期

关键词：

serotonin transporter gene; bipolar affective disorder; unipolar affective disorder;

D O I：

10.1016/S0304-3940(98)00677-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To explore the involvement of serotonin transporter (5HTT) in mood disorder, we studied two polymorphisms of the 5HTT gene (a variable number of tandem repeats in the second intron (VNTR) and a 44 bp insertion/deletion in the 5HTT linked polymorphic region (5-HTTLPR)) in a sample of unipolar and bipolar patients and controls. Homozygosity for the short variant of the 5-HTTLPR was significantly more frequent in bipolar patients than in controls (chi(2) = 4.68, d.f. = 1, P = 0.03) whereas there was no difference between bipolar patients and controls for allele distribution, suggesting a recessive effect. The interaction between the two markers suggests that the two polymorphisms probably have independent effects to determine the susceptibility to affective disorder. Further studies are required to identify the precise phenotype associated with 5HTT polymorphisms in depressed patients. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：143 / 146

页数：4

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