Human immunodeficiency virus-1 vaccine design: where do we go now?

被引:19
作者
Wijesundara, Danushka K. [1 ]
Jackson, Ronald J. [1 ]
Ramshaw, Ian A. [1 ]
Ranasinghe, Charani [1 ]
机构
[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Emerging Pathogens & Vaccines, Canberra, ACT 2601, Australia
关键词
HIV-1; vaccines; mucosal immunity; prime-boost vaccination; T-cell avidity; cytokines/chemokines; CD8(+) T-CELLS; MUCOSAL IMMUNE-RESPONSES; PREVENT HIV-1 INFECTION; AIDS VACCINE; VIRAL REPLICATION; DENDRITIC CELLS; RHESUS-MONKEYS; ANTIBODY; 2G12; DOUBLE-BLIND; EX-VIVO;
D O I
10.1038/icb.2010.118
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Numerous human immunodeficiency virus (HIV)-1 vaccines have been developed over the last three decades, but to date an effective HIV-1 vaccine that can be used for prophylactic or therapeutic purposes in humans has not been identified. The failures and limited successes of HIV-1 vaccines have highlighted the gaps in our knowledge with regard to fundamental immunity against HIV-1 and have provided insights for vaccine strategies that may be implemented for designing more effective HIV-1 vaccines in the future. Recent studies have shown that robust mucosal immunity, high avidity and polyfunctional T cells, and broadly neutralizing antibodies are important factors governing the induction of protective immunity against HIV-1. Furthermore, optimization of vaccine delivery methods for DNA or live viral vector-based vaccines, elucidating the immune responses of individuals who remain resistant to HIV-1 infections and also understanding the core immune responses mediating protection against simian immunodeficiency viruses (SIV) and HIV-1 in animal models following vaccination, are key aspects to be regarded for designing more effective HIV-1 vaccines in the future. Immunology and Cell Biology (2011) 89, 367-374; doi:10.1038/icb.2010.118; published online 19 October 2010
引用
收藏
页码:367 / 374
页数:8
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