A Mild Negishi Cross-Coupling of 2-Heterocyclic Organozinc Reagents and Aryl Chlorides

被引：66

作者：

Luzung, Michael R. ^{[1
]}

Patel, Jigar S. ^{[1
]}

Yin, Jingjun ^{[1
]}

机构：

[1] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 23期

关键词：

BORONIC ACIDS; CATALYST; HALIDES; 2-PYRIDYL; AMINATION; BROMIDES; ESTERS;

D O I：

10.1021/jo1018798

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild Negishi cross-coupling of 2-heterocyclic organozinc reagents and aryl chlorides is described. The use of Pd-2(dba)(3) and X-Phos as a ligand provides high yields for many examples. An efficient method to generate the organozinc reagents at room temperature is also demonstrated.

引用

页码：8330 / 8332

页数：3

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