Added value of deep learning-based computer-aided diagnosis and shear wave elastography to b-mode ultrasound for evaluation of breast masses detected by screening ultrasound

被引:18
作者
Kim, Min Young [1 ,2 ,3 ]
Kim, Soo-Yeon [1 ,2 ,3 ]
Kim, Yeon Soo [1 ,2 ,3 ]
Kim, Eun Sil [1 ,2 ,3 ]
Chang, Jung Min [1 ,2 ,3 ]
机构
[1] Seoul Natl Univ Hosp, Dept Radiol, Seoul, South Korea
[2] Seoul Natl Coll Med, Dept Radiol, Seoul, South Korea
[3] Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul, South Korea
关键词
breast; computer-aided diagnosis; deep learning; screening; shear wave elastography; ultrasound; US; PERFORMANCE; AGREEMENT; MAMMOGRAPHY; CANCERS; WOMEN; ULTRASONOGRAPHY; LEXICON; BENIGN;
D O I
10.1097/MD.0000000000026823
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Low specificity and operator dependency are the main problems of breast ultrasound (US) screening. We investigated the added value of deep learning-based computer-aided diagnosis (S-Detect) and shear wave elastography (SWE) to B-mode US for evaluation of breast masses detected by screening US. Between February 2018 and June 2019, B-mode US, S-Detect, and SWE were prospectively obtained for 156 screening US-detected breast masses in 146 women before undergoing US-guided biopsy. S-Detect was applied for the representative B-mode US image, and quantitative elasticity was measured for SWE. Breast Imaging Reporting and Data System final assessment category was assigned for the datasets of B-mode US alone, B-mode US plus S-Detect, and B-mode US plus SWE by 3 radiologists with varied experience in breast imaging. Area under the receiver operator characteristics curve (AUC), sensitivity, and specificity for the 3 datasets were compared using Delong's method and McNemar test. Of 156 masses, 10 (6%) were malignant and 146 (94%) were benign. Compared to B-mode US alone, the addition of S-Detect increased the specificity from 8%-9% to 31%-71% and the AUC from 0.541-0.545 to 0.658-0.803 in all radiologists (All P < .001). The addition of SWE to B-mode US also increased the specificity from 8%-9% to 41%-75% and the AUC from 0.541-0.545 to 0.709-0.823 in all radiologists (All P < .001). There was no significant loss in sensitivity when either S-Detect or SWE were added to B-mode US. Adding S-Detect or SWE to B-mode US improved the specificity and AUC without loss of sensitivity.
引用
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页数:10
相关论文
共 37 条
[1]   Breast Imaging Reporting and Data System Lexicon for US: Interobserver Agreement for Assessment of Breast Masses [J].
Abdullah, Nouf ;
Mesurolle, Benoit ;
El-Khoury, Mona ;
Kao, Ellen .
RADIOLOGY, 2009, 252 (03) :665-672
[2]   Deep learning [J].
LeCun, Yann ;
Bengio, Yoshua ;
Hinton, Geoffrey .
NATURE, 2015, 521 (7553) :436-444
[3]   Diagnostic Performance of Quantitative Shear Wave Elastography in the Evaluation of Solid Breast Masses: Determination of the Most Discriminatory Parameter [J].
Au, Frederick Wing-Fa ;
Ghai, Sandeep ;
Moshonov, Hadas ;
Kahn, Harriette ;
Brennan, Cressida ;
Dua, Hemi ;
Crystal, Pavel .
AMERICAN JOURNAL OF ROENTGENOLOGY, 2014, 203 (03) :W328-W336
[4]   Characteristics of breast cancers detected by ultrasound screening in women with negative mammograms [J].
Bae, Min Sun ;
Han, Wonshik ;
Koo, Hye Ryoung ;
Cho, Nariya ;
Chang, Jung Min ;
Yi, Ann ;
Park, In-Ae ;
Noh, Dong-Young ;
Choi, Woo Suk ;
Moon, Woo Kyung .
CANCER SCIENCE, 2011, 102 (10) :1862-1867
[5]   Focal breast lesion characterization according to the BI-RADS US lexicon: role of a computer-aided decision-making support [J].
Bartolotta, Tommaso Vincenzo ;
Orlando, Alessia ;
Cantisani, Vito ;
Matranga, Domenica ;
Ienzi, Raffele ;
Cirino, Alessandra ;
Amato, Francesco ;
Di Vittorio, Maria Laura ;
Midiri, Massimo ;
Lagalla, Roberto .
RADIOLOGIA MEDICA, 2018, 123 (07) :498-506
[6]   Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer [J].
Berg, Wendie A. ;
Blume, Jeffrey D. ;
Cormack, Jean B. ;
Mendelson, Ellen B. ;
Lehrer, Daniel ;
Bohm-Velez, Marcela ;
Pisano, Etta D. ;
Jong, Roberta A. ;
Evans, W. Phil ;
Morton, Marilyn J. ;
Mahoney, Mary C. ;
Larsen, Linda Hovanessian ;
Barr, Richard G. ;
Farria, Dione M. ;
Marques, Helga S. ;
Boparai, Karan .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (18) :2151-2163
[7]   Operator dependence of physician-performed whole-breast US: Lesion detection and characterization [J].
Berg, Wendie A. ;
Blume, Jeffrey D. ;
Cormack, Jean B. ;
Mendelson, Ellen B. .
RADIOLOGY, 2006, 241 (02) :355-365
[8]   Shear-wave Elastography Improves the Specificity of Breast US: The BE1 Multinational Study of 939 Masses [J].
Berg, Wendie A. ;
Cosgrove, David O. ;
Dore, Caroline J. ;
Schaefer, Fritz K. W. ;
Svensson, William E. ;
Hooley, Regina J. ;
Ohlinger, Ralf ;
Mendelson, Ellen B. ;
Balu-Maestro, Catherine ;
Locatelli, Martina ;
Tourasse, Christophe ;
Cavanaugh, Barbara C. ;
Juhan, Valerie ;
Stavros, A. Thomas ;
Tardivon, Anne ;
Gay, Joel ;
Henry, Jean-Pierre ;
Cohen-Bacrie, Claude .
RADIOLOGY, 2012, 262 (02) :435-449
[9]   Interexamination variation of whole breast ultrasound [J].
Bosch, AM ;
Kessels, AGH ;
Beets, GL ;
Vranken, KLCG ;
Borstlap, AC ;
Von Meyenfeldt, MF ;
van Engelshoven, JMA .
BRITISH JOURNAL OF RADIOLOGY, 2003, 76 (905) :328-331
[10]   Radiologist-performed hand-held ultrasound screening at average risk of breast cancer: results from a single health screening center [J].
Chang, Jung Min ;
Koo, Hye Ryoung ;
Moon, Woo Kyung .
ACTA RADIOLOGICA, 2015, 56 (06) :652-658