Eplerenone deceases aldosterone salt-induced cardiac fibrosis and reduces oxidative stress in angiotensin II type 1a knockout mice via Rho-kinase inhibition

被引：0
|
作者：
Kagiyama, Shuntarou [1 ]
Matsumura, Kiyoshi [1 ]
Iida, Mitsuo [1 ]
机构：
[1] Kyushu Univ, Fukuoka 812, Japan
来源：
HYPERTENSION | 2008年 / 52卷 / 04期
关键词：
D O I：
暂无
中图分类号：
R6 [外科学];
学科分类号：
1002 ; 100210 ;
摘要：
引用
收藏
页码：E41 / E41
页数：1
相关论文
共 19 条
  • [1] Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice
    Kagiyama, Shuntaro
    Matsumura, Kiyoshi
    Goto, Kenichi
    Otsubo, Toshio
    Lida, Mitsuo
    REGULATORY PEPTIDES, 2010, 160 (1-3) : 133 - 139
  • [2] Aldosterone and salt-induced cardiac fibrosis is exaggerated angiotensin II type 1a receptor knockout mice
    Kagiyama, Shuntarou
    Matsumura, Kiyoshi
    Fukuhara, Masayo
    Higuchi, Kanae
    Fujii, Koji
    Iida, Mitsuo
    HYPERTENSION, 2006, 48 (04) : E37 - E37
  • [3] Severe cardiac fibrosis was induced by aldosterone and salt in angiotensin II type 1a knockout mice
    Kagiyama, Shuntaro
    Matsumura, Kiyoshi
    Fukuhara, Masayo
    Higuchi, Kanae
    Fujii, Koji
    Iida, Mitsuo
    JOURNAL OF HYPERTENSION, 2006, 24 : 104 - 104
  • [4] Aldosterone-and-salt-induced cardiac fibrosis is independent from angiotensin II type 1a receptor signaling in mice
    Kagiyama, Shuntaro
    Matsumura, Kiyoshi
    Fukuhara, Masayo
    Sakagami, Kanae
    Fujii, Koji
    Iida, Mitsuo
    HYPERTENSION RESEARCH, 2007, 30 (10) : 979 - 989
  • [5] Aldosterone-and-Salt–Induced Cardiac Fibrosis Is Independent from Angiotensin II Type 1a Receptor Signaling in Mice
    Shuntaro Kagiyama
    Kiyoshi Matsumura
    Masayo Fukuhara
    Kanae Sakagami
    Koji Fujii
    Mitsuo Iida
    Hypertension Research, 2007, 30 : 979 - 989
  • [6] Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice
    Wang, YX
    da Cunha, V
    Martin-McNulty, B
    Vincelette, J
    Li, WW
    Choy, DF
    Halks-Miller, M
    Mahmoudi, M
    Schroeder, M
    Johns, A
    Light, DR
    Dole, WP
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 512 (2-3) : 215 - 222
  • [7] Aldosterone induced IL-18 expression through Endotheline-1 and Angiotensin II via Rho, Rho-kinase and PPAR in cardiomyocytes
    Doi, T.
    Sakoda, T.
    Akagami, T.
    Naka, T.
    Tsujino, T.
    Masuyama, T.
    Ohyanagi, M.
    EUROPEAN HEART JOURNAL, 2007, 28 : 8 - 8
  • [8] Persistent cardiac aldosterone synthesis in angiotensin II type 1A receptor-knockout mice after myocardial infarction
    Katada, J
    Meguro, T
    Saito, H
    Ohashi, A
    Anzai, T
    Ogawa, S
    Yoshikawa, T
    CIRCULATION, 2005, 111 (17) : 2157 - 2164
  • [9] Mechanical stretch activates tyrosine kinase pathways in cardiac myocytes of angiotensin II type 1a receptor knockout mice
    Kudoh, S
    Komuro, I
    Hiroi, Y
    Sugaya, T
    Murakami, K
    Takekoshi, N
    Yazaki, Y
    CIRCULATION, 1998, 98 (17) : 624 - 624
  • [10] Pharmacological and genetic blockades of angiotensin II type 1A receptors markedly improve cardiac fibrosis in guanylyl cyclase A receptor knockout mice
    Kishimoto, I
    Li, YH
    Harada, M
    Kuwahara, K
    Izumi, T
    Takahashi, N
    Kawakami, R
    Nakagawa, Y
    Nakanishi, M
    Adachi, Y
    Tanimoto, K
    Nakao, K
    CIRCULATION, 2001, 104 (17) : 281 - 281
12