Multi-scale modelling of elastic moduli of trabecular bone

被引：54

作者：

Hamed, Elham ^{[1
]}

Jasiuk, Iwona ^{[1
]}

Yoo, Andrew ^{[2
]}

Lee, YikHan ^{[1
]}

Liszka, Tadeusz ^{[3
]}

机构：

[1] Univ Illinois, Dept Mech Sci & Engn, Urbana, IL 61801 USA

[2] Ethicon Endosurg, Cincinnati, OH 45242 USA

[3] Altair Engn Inc, Austin, TX 78757 USA

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2012年 / 9卷 / 72期

基金：

美国国家科学基金会;

关键词：

trabecular bone; elastic moduli; hierarchical structure; multi-scale modelling; nanocomposite; microCT-based finite-element modelling; MINERALIZED COLLAGEN FIBRILS; MECHANICAL-PROPERTIES; CANCELLOUS BONE; CORTICAL BONE; MANDIBULAR CONDYLE; MOLECULAR COLLAGEN; APPARENT MODULUS; TISSUE MODULUS; CONSTANTS; PREDICTION;

D O I：

10.1098/rsif.2011.0814

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We model trabecular bone as a nanocomposite material with hierarchical structure and predict its elastic properties at different structural scales. The analysis involves a bottom-up multi-scale approach, starting with nanoscale (mineralized collagen fibril) and moving up the scales to sub-microscale (single lamella), microscale (single trabecula) and mesoscale (trabecular bone) levels. Continuum micromechanics methods, composite materials laminate theory and finite-element methods are used in the analysis. Good agreement is found between theoretical and experimental results.

引用

页码：1654 / 1673

页数：20

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