A Small-Footprint, High-Capacity Flow Reactor for UV Photochemical Synthesis on the Kilogram Scale

被引：116

作者：

Elliott, Luke D. ^{[1
]}

Berry, Malcolm ^{[2
]}

Harji, Bashir ^{[4
]}

Klauber, David ^{[3
]}

Leonard, John ^{[3
]}

Booker-Milburn, Kevin I. ^{[1
]}

机构：

[1] Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England

[2] GlaxoSmithKline, Gunnels Wood Rd, Stevenage SG1 2NY, Herts, England

[3] AstraZeneca, Pharmaceut Sci, Silk Rd Business Pk, Macclesfield SK10 2NA, Cheshire, England

[4] Cambridge Reactor Design Ltd, Brookfield Business Ctr, Unit D2, Twentypence Rd, Cottenham CB24 8PS, England

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2016年 / 20卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

MULTITUBULAR PHOTOREACTOR; LIGHT; REARRANGEMENT; FLUORINATION; TECHNOLOGY; CHEMISTRY; AZIDES; BATCH; ACIDS; FIELD;

D O I：

10.1021/acs.oprd.6b00277

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The development of a highly compact and powerful reactor for synthetic organic photochemistry is described enabling a 10-fold reduction in reaction times, with up to 30% more power efficiency than previous fluorinated ethylene propylene tube reactors. Two reactions gave over 1 kg of product in 24 h. Two other reactions had productivities of 4 and 8 kg in 24 h. The reactor consists of a succession of quartz tubes connected together in series and arranged axially around a variable power mercury lamp. This compact and relatively simple device can be safely operated in a standard fumehood.

引用

页码：1806 / 1811

页数：6

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