Vibrio cholerae Autoinducer CAI-1 Interferes with Pseudomonas aeruginosa Quorum Sensing and Inhibits its Growth

被引:9
作者
Ganin, Hadas [1 ,2 ]
Danin-Poleg, Yael [3 ]
Kashi, Yechezkel [3 ]
Meijler, Michael M. [1 ,2 ]
机构
[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel
[3] Technion Israel Inst Technol, Dept Biotechnol & Food Engn, IL-32000 Haifa, Israel
基金
以色列科学基金会;
关键词
VIRULENCE GENE-EXPRESSION; STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILM; SMALL-MOLECULE; ANTIBIOTICS; LACTONES; AZITHROMYCIN; INFECTIONS; MEMBRANE; SIGNALS;
D O I
10.1021/cb2004675
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The human,patliogen. Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main auto-inducer is CAI-1 We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS, in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were Unaffected and we suggest a possible mechanism for these effects, based on membrane perturbation studies.
引用
收藏
页码:659 / 665
页数:7
相关论文
共 40 条
[21]   Defining the Mode of Action of Tetramic Acid Antibacterials Derived from Pseudomonas aeruginosa Quorum Sensing Signals [J].
Lowery, Colin A. ;
Park, Junguk ;
Gloeckner, Christian ;
Meijler, Michael M. ;
Mueller, Ryan S. ;
Boshoff, Helena I. ;
Ulrich, Ricky L. ;
Barry, Clifton E., III ;
Bartlett, Douglas H. ;
Kravchenko, Vladimir V. ;
Kaufmann, Gunnar F. ;
Janda, Kim D. .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (40) :14473-14479
[22]   Inhibition of luminescence and virulence in the black tiger prawn (Penaeus monodon) pathogen Vibrio harveyi by intercellular signal antagonists [J].
Manefield, M ;
Harris, L ;
Rice, SA ;
De Nys, R ;
Kjelleberg, S .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (05) :2079-2084
[23]   Quorum sensing in bacteria [J].
Miller, MB ;
Bassler, BL .
ANNUAL REVIEW OF MICROBIOLOGY, 2001, 55 :165-199
[24]   BACTERIAL BIOLUMINESCENCE - ITS CONTROL AND ECOLOGICAL SIGNIFICANCE [J].
NEALSON, KH ;
HASTINGS, JW .
MICROBIOLOGICAL REVIEWS, 1979, 43 (04) :496-518
[25]   Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems [J].
Ng, Wai-Leung ;
Perez, Lark J. ;
Wei, Yunzhou ;
Kraml, Christina ;
Semmelhack, Martin F. ;
Bassler, Bonnie L. .
MOLECULAR MICROBIOLOGY, 2011, 79 (06) :1407-1417
[26]   N-acylhomoserine lactones antagonize virulence gene expression and quorum sensing in Staphylococcus aureus [J].
Qazi, S ;
Middleton, B ;
Muharram, SH ;
Cockayne, A ;
Hill, P ;
O'Shea, P ;
Chhabra, SR ;
Cámara, M ;
Williams, P .
INFECTION AND IMMUNITY, 2006, 74 (02) :910-919
[27]  
Rice Scott A., 1999, Journal of Molecular Microbiology and Biotechnology, V1, P23
[28]   The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule [J].
Schauder, S ;
Shokat, K ;
Surette, MG ;
Bassler, BL .
MOLECULAR MICROBIOLOGY, 2001, 41 (02) :463-476
[29]   More than a signal: non-signaling properties of quorum sensing molecules [J].
Schertzer, Jeffrey W. ;
Boulette, Megan L. ;
Whiteley, Marvin .
TRENDS IN MICROBIOLOGY, 2009, 17 (05) :189-195
[30]   Effects of antibiotics on quorum sensing in pseudomonas aeruginosa [J].
Skindersoe, Mette E. ;
Alhede, Morten ;
Phipps, Richard ;
Yang, Liang ;
Jensen, Peter O. ;
Rasmussen, Thomas B. ;
Bjarnsholt, Thomas ;
Tolker-Nielsen, Tim ;
Hoiby, Niels ;
Givskov, Michael .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (10) :3648-3663