Vibrio cholerae Autoinducer CAI-1 Interferes with Pseudomonas aeruginosa Quorum Sensing and Inhibits its Growth

被引：9

作者：

Ganin, Hadas ^{[1
,2
]}

Danin-Poleg, Yael ^{[3
]}

Kashi, Yechezkel ^{[3
]}

Meijler, Michael M. ^{[1
,2
]}

机构：

[1] Ben Gurion Univ Negev, Dept Chem, IL-84105 Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Natl Inst Biotechnol Negev, IL-84105 Beer Sheva, Israel

[3] Technion Israel Inst Technol, Dept Biotechnol & Food Engn, IL-32000 Haifa, Israel

来源：

ACS CHEMICAL BIOLOGY | 2012年 / 7卷 / 04期

基金：

以色列科学基金会;

关键词：

VIRULENCE GENE-EXPRESSION; STAPHYLOCOCCUS-AUREUS; BACTERIAL BIOFILM; SMALL-MOLECULE; ANTIBIOTICS; LACTONES; AZITHROMYCIN; INFECTIONS; MEMBRANE; SIGNALS;

D O I：

10.1021/cb2004675

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human,patliogen. Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main auto-inducer is CAI-1 We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS, in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were Unaffected and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

引用

页码：659 / 665

页数：7

共 40 条

[1] A novel and sensitive method for the quantification of N-3-oxoacyl homoserine lactones using gas chromatography-mass spectrometry:: application ito a model bacterial biofilm [J].

Charlton, TS ;

de Nys, R ;

Netting, A ;

Kumar, N ;

Hentzer, M ;

Givskov, M ;

Kjelleberg, S .

ENVIRONMENTAL MICROBIOLOGY, 2000, 2 (05) :530-541

[2] Effect of bile on the cell surface permeability barrier and efflux system of Vibrio cholerae [J].

Chatterjee, A ;

Chaudhuri, S ;

Saha, G ;

Gupta, S ;

Chowdhury, R .

JOURNAL OF BACTERIOLOGY, 2004, 186 (20) :6809-6814

[3] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[4] Vibrio cholerae strain typing and Phylogeny study based on simple sequence repeats [J].

Danin-Poleg, Yael ;

Cohen, Lyora A. ;

Gancz, Hanan ;

Broza, Yoav Y. ;

Goldshmidt, Hanoh ;

Malul, Elinor ;

Valinsky, Lea ;

Lerner, Larisa ;

Broza, Meir ;

Kashi, Yechezkel .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (03) :736-746

[5] The involvement of cell-to-cell signals in the development of a bacterial biofilm [J].

Davies, DG ;

Parsek, MR ;

Pearson, JP ;

Iglewski, BH ;

Costerton, JW ;

Greenberg, EP .

SCIENCE, 1998, 280 (5361) :295-298

[6] Bacterial quorum sensing in pathogenic relationships [J].

de Kievit, TR ;

Iglewski, BH .

INFECTION AND IMMUNITY, 2000, 68 (09) :4839-4849

[7] Environmental regulation of Pseudomonas aeruginosa PAO1 las and rhl quorum-sensing systems [J].

Duan, Kangmin ;

Surette, Michael G. .

JOURNAL OF BACTERIOLOGY, 2007, 189 (13) :4827-4836

[8] Antibiotics as signals that trigger specific bacterial responses [J].

Fajardo, Alicia ;

Martinez, Jose L. .

CURRENT OPINION IN MICROBIOLOGY, 2008, 11 (02) :161-167

[9] Listening in on bacteria: Acyl-homoserine lactone signalling [J].

Fuqua, C ;

Greenberg, EP .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (09) :685-695

[10] Small molecule inhibitors of bacterial quorum sensing and biofilm formation [J].

Geske, GD ;

Wezeman, RJ ;

Siegel, AP ;

Blackwell, HE .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (37) :12762-12763

← 1 2 3 4 →