Hypertension and cerebrovascular dysfunction

被引：428

作者：

Iadecola, Costantino ^{[1
]}

Davisson, Robin L. ^{[2
]}

机构：

[1] Weill Cornell Med Coll, Dept Neurol & Neurosci, Div Neurobiol, New York, NY 10021 USA

[2] Weill Cornell Med Coll, Dept Cell & Dev Biol, New York, NY 10021 USA

来源：

CELL METABOLISM | 2008年 / 7卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2008.03.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Essential hypertension has devastating effects on the brain, being the major cause of stroke and a leading cause of dementia. Hypertension alters the structure of cerebral blood vessels and disrupts intricate vaso-regulatory mechanisms that assure an adequate blood supply to the brain. These alterations threaten the cerebral blood supply and increase the susceptibility of the brain to ischemic injury as well as Alzheimer's disease. This review focuses on the mechanisms by which hypertension disrupts cerebral blood vessels, highlighting recent advances and outstanding issues.

引用

页码：476 / 484

页数：9

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