Pyrrolo[3,4-c]pyridine-Based Fluorescent Chemosensor for Fe3+/Fe2+ Sensitivity and Their Application in Living HepG2 Cells

被引：23

作者：

Maity, Pampa ^{[1
]}

Naskar, Barnali ^{[1
]}

Goswami, Sanchita ^{[1
]}

Prodhan, Chandraday ^{[2
]}

Chaudhuri, Tandrima ^{[3
]}

Chaudhuri, Keya ^{[2
]}

Mukhopadhyay, Chhanda ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India

[2] Indian Inst Chem Biol, CSIR, Mol & Human Genet Div, 4 Raja SC Mallick Rd, Kolkata 700032, India

[3] Dr BN Dutta Smriti Mahavidyalaya, Dept Chem, Burdwan 713407, W Bengal, India

来源：

ACS OMEGA | 2018年 / 3卷 / 12期

关键词：

TURN-ON CHEMOSENSOR; RHODAMINE-BASED CHEMOSENSOR; ENERGY-TRANSFER; AQUEOUS-MEDIUM; FILM SENSORS; FE3+; IRON; PROBE; CU2+; IRON(III);

D O I：

10.1021/acsomega.8b02110

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New 2H-pyrrolo[3,4-c]pyridine-1,3,6(5H)-trione-based fluorophores have been synthesized by a single-step procedure in an ambient reaction condition. By this protocol, a total of 44 new compounds were generated and the photophysical property of 23 compounds was studied in detail. These fluorophores show good fluorescence activity and illustrate high selectivity for Fe3+/Fe2+ cation in the 10(-7) (M) range. Notably, this 2H-pyrrolo[3,4-c]pyridine-1,3,6(5H)-trione moiety is first used as a turn-off chemosensor for the Fe3+/Fe2+ cation. In addition, this probe was further applied for imaging Fe3+ in living HepG2 cells.

引用

页码：18646 / 18655

页数：10

共 65 条

[1] DETERMINATION OF IRON AND 10 OTHER TRACE-ELEMENTS IN THE OPEN OCEAN SEAWATER REFERENCE MATERIAL NASS-3 BY INDUCTIVELY COUPLED PLASMA MASS-SPECTROMETRY [J].

AKATSUKA, K ;

MCLAREN, JW ;

LAM, JW ;

BERMAN, SS .

JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, 1992, 7 (06) :889-894

[2] A rhodamine based fluorescent trivalent sensor (Fe3+, Al3+, Cr3+) with potential applications for live cell imaging and combinational logic circuits and memory devices [J].

Alam, Rabiul ;

Bhowmick, Rahul ;

Islam, Abu Saleh Musha ;

Katarkar, Atul ;

Chaudhuri, Keya ;

Ali, Mahammad .

NEW JOURNAL OF CHEMISTRY, 2017, 41 (16) :8359-8369

[3]

Beutler E, 2001, DRUG METAB DISPOS, V29, P495

[4] A rhodamine based turn-on chemosensor for Fe3+ in aqueous medium and interactions of its Fe3+ complex with HSA [J].

Bhowmick, Rahul ;

Islam, Abu Saleh Musha ;

Giri, Arindam ;

Katarkar, Atul ;

Ali, Mahammad .

NEW JOURNAL OF CHEMISTRY, 2017, 41 (20) :11661-11671

[5] Application of a bismuth film electrode to the voltammetric determination of trace iron using a Fe(III)-TEA-BrO3- catalytic system [J].

Bobrowski, A ;

Nowak, K ;

Zarebski, J .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005, 382 (07) :1691-1697

[6] Role of metal dyshomeostasis in Alzheimer's disease [J].

Bonda, David J. ;

Lee, Hyoung-gon ;

Blair, Jeffrey A. ;

Zhu, Xiongwei ;

Perry, George ;

Smith, Mark A. .

METALLOMICS, 2011, 3 (03) :267-270

[7] Iron(II) Binding to Amyloid-β, the Alzheimer's Peptide [J].

Bousejra-ElGarah, Fatima ;

Bijani, Christian ;

Coppel, Yannick ;

Faller, Peter ;

Hureau, Christelle .

INORGANIC CHEMISTRY, 2011, 50 (18) :9024-9030

[8] On the development of sensor molecules that display FeIII-amplified fluorescence [J].

Bricks, JL ;

Kovalchuk, A ;

Trieflinger, C ;

Nofz, M ;

Büschel, M ;

Tolmachev, AI ;

Daub, J ;

Rurack, K .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (39) :13522-13529

[9] Highly selective chromogenic and redox or fluorescent sensors of Hg2+ in aqueous environment based on 1,4-disubstituted azines [J].

Caballero, A ;

Martínez, R ;

Lloveras, V ;

Ratera, I ;

Vidal-Gancedo, J ;

Wurst, K ;

Tárraga, A ;

Molina, P ;

Veciana, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (45) :15666-15667

[10] Iron regulatory proteins in pathobiology [J].

Cairo, G ;

Pietrangelo, A .

BIOCHEMICAL JOURNAL, 2000, 352 :241-250

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