Cancer, hear my battle CRY

被引：16

作者：

Chan, Alanna B. ^{[1
]}

Lamia, Katja A. ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd,MB-21, La Jolla, CA 92037 USA

来源：

JOURNAL OF PINEAL RESEARCH | 2020年 / 69卷 / 01期

关键词：

cell cycle; circadian clocks; circadian rhythm; cryptochromes; DNA repair; oncogenes carcinogenesis; CIRCADIAN GENE-EXPRESSION; FACTOR PERIOD 2; CELL-CYCLE; DNA-DAMAGE; NUCLEAR RECEPTORS; DEREGULATED EXPRESSION; CHECKPOINT RESPONSE; P53; STABILITY; SHIFT-WORK; TIME ZONE;

D O I：

10.1111/jpi.12658

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Circadian clocks are cell-autonomous self-sustaining oscillators that allow organisms to anticipate environmental changes throughout the solar day and persist in nearly every cell examined. Environmental or genetic disruption of circadian rhythms increases the risk of several types of cancer, but the underlying mechanisms are not well understood. Here, we discuss evidence connecting circadian rhythms-with emphasis on the cryptochrome proteins (CRY1/2)-to cancer through in vivo models, mechanisms involving known tumor suppressors and oncogenes, chemotherapeutic efficacy, and human cancer risk.

引用

页数：12

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