Alkene synthesis: elimination of arenesulfinic acid from alkyl aryl sulfones using potassium trimethylsilanolate as base

被引：21
作者：
Baker-Glenn, CAG
Barrett, AGM
Gray, AA
Procopiou, PA
Ruston, M
机构：
[1] GlaxoSmithKline Med Res Ctr, Stevenage SG1 2NY, Herts, England
[2] Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 43期
基金：
英国工程与自然科学研究理事会;
关键词：
sulfone; elimination; alkene synthesis; potassium trimethylsilanolate; arenesulfinate salt;
D O I：
10.1016/j.tetlet.2005.08.097
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of potassium trimethylsilanolate as base to induce elimination of potassium arenesulfinate from alkyl aryl sulfones to produce E-alkenes is described. The reaction was appropriate for substrates containing a benzyl or allyl group alpha to the sulfone residue. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7427 / 7430
页数：4
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