Responsiveness of rat vestibular ganglion neurons to exogenous neurotrophic factors during postnatal development in dissociated cultures

被引：3

作者：

Chihara, Yasuhiro ^{[1
,2
]}

Iwasaki, Shinichi ^{[2
]}

Kondo, Kenji ^{[2
]}

Yamasoba, Tatsuya ^{[2
]}

机构：

[1] Kameda Med Ctr, Dept Otolaryngol, Kamogawa, Chiba 2968602, Japan

[2] Univ Tokyo, Fac Med, Dept Otolaryngol Head & Neck Surg, Tokyo 113, Japan

来源：

BRAIN RESEARCH | 2011年 / 1408卷

关键词：

Vestibular; Ganglion; Neurotrophin; BDNF; NT-3; GDNF; NERVE GROWTH-FACTOR; INNER-EAR; TARGET INNERVATION; SIGNALING PATHWAYS; FIRING PROPERTIES; SENSORY NEURONS; MESSENGER-RNAS; GDNF FAMILY; SPINAL-CORD; BDNF;

D O I：

10.1016/j.brainres.2011.06.058

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the responsiveness of rat vestibular ganglion neurons (VGNs) to exogenous neurotrophic factors, BDNF, NT-3, and GDNF, during postnatal development in dissociated cultures. VGNs were obtained from postnatal days (P) 1, 3, 7, and 14. After two days in culture, the survival of VGNs in control cultures without any exogenous neurotrophic factors was greater in younger (P1 or 3) rats than older (P7 or 14) rats. None of the three neurotrophic factors used facilitated survival of VGNs from older rats while only BDNF facilitated survival of VGNs from younger rats. BDNF was also effective both for increasing neurite sprouting in VGNs from younger rats and for neurite extension in VGNs from each of the postnatal ages. VGNs from P1 rats showed responsiveness to all three neurotrophic factors in their neurite sprouting. Developmental changes of VGNs in their responsiveness to exogenous neurotrophic factors should be considered in treating or preventing neuronal degeneration caused by peripheral vestibular lesions. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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