A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones

被引：15

作者：

Wang, Bin ^{[1
,2
]}

Li, Zeng ^{[1
]}

Wang, Xiao Ning ^{[1
]}

Tan, Jia Heng ^{[1
]}

Gu, Lian Quan ^{[1
]}

Huang, Zhi Shu ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Xiangnan Univ, Dept Chem & Life Sci, Chenzhou 423000, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2011年 / 22卷 / 08期

关键词：

Quinazolin-4(3H)-ones; Synthesis; Aminobenzamide; Orthoester; AROMATIC HETEROCYCLES; DERIVATIVES; DESIGN;

D O I：

10.1016/j.cclet.2011.01.034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new approach to the facile synthesis of 2-substituted-quinazolin-4(3H)-ones and its derivatives using the condensation reaction of substituted 2-aminobenzamide and orthoesters is reported. (C) 2011 Zhi Shu Huang. Published by Elsevier BA,, on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：951 / 953

页数：3

共 18 条

[1] A novel method for the synthesis of 4(3H)-quinazolinones [J].

Abdel-Jalil, RJ ;

Voelter, W ;

Saeed, M .

TETRAHEDRON LETTERS, 2004, 45 (17) :3475-3476

[2] H-Y zeolites induced heterocyclization:: Highly efficient synthesis of substituted-quinazolin-4(3H)ones under microwave irradiation [J].

Bakavoli, M. ;

Sabzevari, O. ;

Rahimizadeh, M. .

CHINESE CHEMICAL LETTERS, 2007, 18 (05) :533-535

[3]

CHAN JH, 1997, J HETEROCYCLIC CHEM, V34, P34

[4] Synthesis of quinazolinones and quinazolines [J].

Connolly, DJ ;

Cusack, D ;

O'Sullivan, TP ;

Guiry, PJ .

TETRAHEDRON, 2005, 61 (43) :10153-10202

[5] RATIONAL DESIGN OF QUINAZOLINE-BASED IRREVERSIBLE INHIBITORS OF HUMAN ERYTHROCYTE PURINE NUCLEOSIDE PHOSPHORYLASE [J].

DEMPCY, RO ;

SKIBO, EB .

BIOCHEMISTRY, 1991, 30 (34) :8480-8487

[6]

GACKENHEIMER SL, 1996, EXP THER, V73, P113

[7] Synthesis of aromatic heterocycles [J].

Gilchrist, TL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 2001, (20) :2491-2515

[8] Synthesis of aromatic heterocycles [J].

Gilchrist, TL .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (20) :2849-2866

[9] A novel multi-component synthesis of 4-arylaminoquinazolines [J].

Heravi, Majid M. ;

Sadjadi, Samaheh ;

Haj, Negar Mokhtari ;

Oskooie, Hossein A. ;

Shoar, Rahim Hekmat ;

Bamoharram, Fatemeh F. .

TETRAHEDRON LETTERS, 2009, 50 (08) :943-945

[10] Reaction of anthranilic acid with orthoesters: a new facile one-pot synthesis of 2-substituted 4H-3,1-benzoxazin-4-ones [J].

Khajavi, MS ;

Montazari, N ;

Hosseini, SSS .

JOURNAL OF CHEMICAL RESEARCH-S, 1997, (08) :286-287

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