Temporal Trends, Characteristics, and Outcomes of Infective Endocarditis After Transcatheter Aortic Valve Replacement

被引：31

作者：

Del Val, David ^{[1
]}

Abdel-Wahab, Mohamed ^{[2
,3
]}

Linke, Axel ^{[2
,4
]}

Durand, Eric ^{[5
]}

Ihlemann, Nikolaj ^{[6
]}

Urena, Marina ^{[7
]}

Pellegrini, Costanza ^{[8
]}

Giannini, Francesco ^{[9
,10
]}

Landt, Martin ^{[3
]}

Auffret, Vincent ^{[11
]}

Sinning, Jan Malte ^{[12
]}

Cheema, Asim ^{[13
,14
]}

Nombela-Franco, Luis ^{[15
]}

Chamandi, Chekrallah ^{[16
]}

Campelo-Parada, Francisco ^{[17
]}

Munoz-Garcia, Antonio ^{[18
]}

Herrmann, Howard C. ^{[19
]}

Testa, Luca ^{[20
]}

Won-Keun, Kim ^{[21
]}

Carlos Castillo, Juan ^{[22
]}

Alperi, Alberto ^{[23
]}

Tchetche, Didier ^{[24
]}

Bartorelli, Antonio ^{[25
]}

Kapadia, Samir ^{[26
]}

Stortecky, Stefan ^{[27
]}

Amat-Santos, Ignacio ^{[28
]}

Wijeysundera, Harindra C. ^{[29
]}

Lisko, John ^{[30
]}

Gutierrez-Ibanes, Enrique ^{[31
]}

Serra, Vicenc ^{[32
]}

Salido, Luisa ^{[33
]}

Alkhodair, Abdullah ^{[34
]}

Livi, Ugolino ^{[35
]}

Chakravarty, Tarun ^{[36
]}

Lerakis, Stamatios ^{[30
,37
]}

Vilalta, Victoria ^{[38
]}

Regueiro, Ander ^{[39
]}

Romaguera, Rafael ^{[40
]}

Barbanti, Marco ^{[41
]}

Masson, Jean-Bernard ^{[42
]}

Maes, Frederic ^{[43
]}

Fiorina, Claudia ^{[44
]}

Miceli, Antonio ^{[45
,46
]}

Kodali, Susheel ^{[47
]}

Ribeiro, Henrique B. ^{[48
]}

Mangione, Jose Armando ^{[49
]}

de Brito, Fabio Sandoli ^{[48
]}

Actis Dato, Guglielmo Mario ^{[50
]}

Rosato, Francesco ^{[51
]}

Ferreira, Maria-Cristina ^{[52
]}

机构：

[1] Laval Univ, Quebec Heart & Lung Inst, 2725 Chemin Ste Foy, Quebec City, PQ G1V 4GS, Canada

[2] Univ Leipzig, Heart Ctr Leipzig, Leipzig, Germany

[3] Segeberger Kliniken, Heart Ctr, Bad Segeberg, Germany

[4] Tech Univ Dresden, Herzzentrum Dresden, Dresden, Germany

[5] Univ Rouen, Hop Charles Nicolle, Rouen, France

[6] Righosp, Copenhagen, Denmark

[7] Bichat Hop, Paris, France

[8] Deutsch Herzzentrum Munich, Munich, Germany

[9] Osped San Raffaele, Milan, Italy

[10] Maria Cecilia Hosp, GVM Care & Res, Cotignola, RA, Italy

[11] Ctr Hosp Univ Rennes, Rennes, France

[12] Heart Ctr Bonn, Bonn, Germany

[13] St Michaels Hosp, Toronto, ON, Canada

[14] Southlake Reg Hlth Ctr, Newmarket, ON, Canada

[15] Hosp Clin San Carlos, Cardiovasc Inst, IdISSC, Madrid, Spain

[16] Hop Europeen Georges Pompidou, Paris, France

[17] Hop Rangueil, Toulouse, France

[18] Hosp Univ Virgen de la Victoria, Malaga, Spain

[19] Hosp Univ Penn, 3400 Spruce St, Philadelphia, PA 19104 USA

[20] IRCCS Pol San Donato, Milan, Italy

[21] Kerckhoff Klin, Bad Nauheim, Germany

[22] Hosp Univ Reina Sofia, Cordoba, Spain

[23] Hosp Univ Cent Asturias, Oviedo, Spain

[24] Clin Pasteur, Toulouse, France

[25] Univ Milan, Ctr Cardiol Monzino, IRCCS, Irccs, Italy

[26] Cleveland Clin, Cleveland, OH 44106 USA

[27] Univ Bern, Bern Univ Hosp, Dept Cardiol, Inselspital, Bern, Switzerland

[28] Hosp Clin Univ Valladolid, CIBERCV, Valladolid, Spain

[29] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[30] Emory Univ, Sch Med, Atlanta, GA USA

[31] Hosp Gregorio Maranon, Inst Invest Univ Gregorio Maranon, Madrid, Spain

[32] Hosp Valle De Hebron, Barcelona, Spain

[33] Hosp Univ Ramon y Cajal, Madrid, Spain

[34] St Pauls Hosp, Vancouver, BC, Canada

[35] Univ Hosp Udine, Udine, Italy

[36] Cedars Sinai Heart Inst, Los Angeles, CA USA

[37] Mt Sinai Hosp, New York, NY 10029 USA

[38] Hosp Badalona Germans Trias & Pujol, Badalona, Spain

[39] Hosp Clin Barcelona, Barcelona, Spain

[40] Hosp Bellvitge Princeps Espanya, Lhospitalet De Llobregat, Spain

[41] Univ Catania, AOU Policlin Vittorio Emanuele, Catania, Italy

[42] Ctr Hosp Univ Montreal, Montreal, PQ, Canada

[43] Clin Univ St Luc, Brussels, Belgium

[44] ASST Spedali Civili Brescia, Brescia, Italy

[45] Fdn Toscana G Monasterio, Massa, Italy

[46] Ist Clin St Ambrogio, Milan, Italy

[47] Columbia Univ, Med Ctr, New York, NY USA

[48] Univ Sao Paulo, Inst Coracao Incor, Heart Inst, Sao Paulo, SP, Brazil

[49] Hosp Beneficencia Portuguesa, Sao Paulo, SP, Brazil

[50] Osped Mauriziano Umberto 1, Turin, Italy

来源：

CLINICAL INFECTIOUS DISEASES | 2021年 / 73卷 / 11期

关键词：

infective endocarditis; transcatheter aortic valve replacement; TAVR; prosthetic valve endocarditis; CONSCIOUS SEDATION; GENERAL-ANESTHESIA; IMPLANTATION; ASSOCIATION; DIAGNOSIS; INSIGHTS; THERAPY; ADULTS;

D O I：

10.1093/cid/ciaa1941

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background. Procedural improvements combined with the contemporary clinical profile of patients undergoing transcatheter aortic valve replacement (TAVR) may have influenced the incidence and outcomes of infective endocarditis (IE) following TAVR. We aimed to determine the temporal trends, characteristics, and outcomes of IE post-TAVR. Methods. Observational study including 552 patients presenting definite IE post-TAVR. Patients were divided in 2 groups according to the timing of TAVR (historical cohort [HC]: before 2014; contemporary cohort [CC]: after 2014). Results. Overall incidence rates of IE were similar in both cohorts (CC vs HC: 5.45 vs 6.52 per 1000 person-years; P = .12), but the rate of early IE was lower in the CC (2.29% vs 4.89%, P < .001). Enterococci were the most frequent microorganism. Most patients presented complicated IE (CC: 67.7%; HC: 69.6%; P = .66), but the rate of surgical treatment remained low (CC: 20.7%; HC: 17.3%; P = .32). The CC exhibited lower rates of in-hospital acute kidney injury (35.1% vs 44.6%; P = .036) and in-hospital (26.6% vs 36.4%; P = .016) and 1-year (37.8% vs 53.5%; P < .001) mortality. Higher logistic EuroScore, Staphylococcus aureus etiology, and complications (stroke, heart failure, and acute renal failure) were associated with in-hospital mortality in multivariable analyses (P < .05 for all). Conclusions. Although overall IE incidence has remained stable, the incidence of early IE has declined in recent years. The microorganism, high rate of complications, and very low rate of surgical treatment remained similar. In-hospital and 1-year mortality rates were high but progressively decreased over time.

引用

页码：E3750 / E3758

页数：9

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