Tumor microenvironment and cancer therapy resistance

被引:283
作者
Sun, Yu [1 ,2 ,3 ,4 ,5 ]
机构
[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai 200031, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Collaborat Innovat Ctr Syst Biomed, Shanghai 200240, Peoples R China
[4] VA Seattle Med Ctr, Seattle, WA 98108 USA
[5] Univ Washington, Dept Med, Seattle, WA 98195 USA
基金
中国国家自然科学基金;
关键词
Tumor microenvironment; Cancer therapy; Acquired resistance; Personalized medicine; CARCINOMA-ASSOCIATED FIBROBLASTS; ENDOTHELIAL GROWTH-FACTOR; HEPATOCELLULAR-CARCINOMA; MOLECULAR PATHWAYS; CELL MOBILIZATION; IMPROVED SURVIVAL; DAMAGE RESPONSES; DRUG-RESISTANCE; BREAST; ANGIOGENESIS;
D O I
10.1016/j.canlet.2015.07.044
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Innate resistance to various therapeutic interventions is a hallmark of cancer. In recent years, however, acquired resistance has emerged as a daunting challenge to anticancer treatments including chemotherapy, radiation and targeted therapy, which abolishes the efficacy of otherwise successful regimens. Cancer cells gain resistance through a variety of mechanisms in both primary and metastatic sites, involving cell intrinsic and extrinsic factors, but the latter often remains overlooked. Mounting evidence suggests critical roles played by the tumor microenvironment (TME) in multiple aspects of cancer progression particularly therapeutic resistance. The TME decreases drug penetration, confers proliferative and antiapoptotic advantages to surviving cells, facilitates resistance without causing genetic mutations and epigenetic changes, collectively modifying disease modality and distorting clinical indices. Recent studies have set the baseline for future investigation on the intricate relationship between cancer resistance and the TME in pathological backgrounds. This review provides an updated outline of research advances in TME biology and highlights the prospect of targeting the TME as an essential strategy to overcome cancer resistance and improve therapeutic outcomes through precise intervention. In the long run, continued inputs into translational medicine remain highly desired to achieve durable responses in the current era of personalized clinical oncology. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:205 / 215
页数:11
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