Difficulties and limitations in conducting translational research in thoracic oncology. A practical example

被引：1

作者：

Meert, A. -P. ^{[1
]}

Ameye, L. ^{[2
]}

Leclercq, N. ^{[1
]}

Paesmans, M. ^{[2
]}

Remmelink, M. ^{[3
]}

Sculier, J. -P. ^{[1
]}

Berghmans, T. ^{[1
]}

机构：

[1] Univ Libre Bruxelles, Inst Jules Bordet, Serv Soins Intensifs Urgences Oncol & Oncol Thora, 1 Rue Heger Bordet, B-1000 Brussels, Belgium

[2] Univ Libre Bruxelles, Inst Jules Bordet, Ctr Data, Brussels, Belgium

[3] Univ Libre Bruxelles, Hop Erasme, Serv Anatomopathol, Brussels, Belgium

来源：

REVUE DES MALADIES RESPIRATOIRES | 2016年 / 33卷 / 07期

关键词：

Lung neoplasm; Chemotherapy; Predictive factors; Response; Survival; CELL LUNG-CANCER; EXPRESSION; SIGNATURES; SURVIVAL; MULTICENTER; C-ERBB-2; BIOPSY; EGFR;

D O I：

10.1016/j.rmr.2015.10.744

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Introduction. In a first study, we identified signatures of 3 mRNAs (semaphorin 3D [SEMA3D], cytokeratin 16 [KRT16] and UL16 binding protein 2 [ULBP2]) associated to response to a cisplatinvinorelbin chemotherapy and to survival of advanced non-small cell lung cancers (NSCLC). Material and methods. The aim of this study was to develop immunohistochemistry tests for KRT16, ULBP2 and SEMA3D and to test proteins expression for prediction of response and survival in biopsies of the same patients. Results. We were not able to reproduce by the protein expression study the signature predicting response to chemotherapy in advanced NSCLC. Conclusion. We highlight the difficulties of translational research in thoracic oncology emphasizing the complexity in obtaining adequate tissue samples and the difficulties in conduction and transposing in routine practice high throughput technique for transcriptomic analyses. (C) 2015 SPLF. Published by Elsevier Masson SAS. All rights reserved.

引用

页码：594 / 599

页数：6

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