Use of adipose tissue in regenerative medicine

被引：10
作者：
Casteilla, L. [1 ,2 ]
Planat-Benard, V. [1 ,2 ]
Bourin, P. [1 ,2 ,3 ]
Laharrague, P. [1 ,2 ]
Cousin, B. [1 ,2 ]
机构：
[1] CNRS, INSERM, UMR UPS EFS 5273, U103, F-31432 Toulouse, France
[2] Univ Toulouse, UMR UPS 5241, F-31432 Toulouse, France
[3] EFS PM, Lab Therapie Cellulaire, F-31300 Toulouse, France
来源：
TRANSFUSION CLINIQUE ET BIOLOGIQUE | 2011年 / 18卷 / 02期
关键词：
Adipose tissue; Stem cell; Stroma; Cell therapy; MESENCHYMAL STEM-CELLS; THERAPY POSITION STATEMENT; COMPLEX PERIANAL FISTULA; UMBILICAL-CORD BLOOD; STROMAL CELLS; BONE-MARROW; MYOCARDIAL-INFARCTION; IN-VIVO; IMMUNOSUPPRESSIVE PROPERTIES; INTERNATIONAL-SOCIETY;
D O I：
10.1016/j.tracli.2011.01.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adipose tissue is abundant and well known for its involvement in obesity and associated metabolic disorders. Its uses in regenerative medicine recently attracted many investigators, as large amounts of this tissue can be easily obtained using liposuction and it contains several populations of immature cells. The largest pool of such cells corresponds to immature stromal cells, called adipose-derived stromal cells (ADSCs). These cells are purified after proteolytic digestion of adipose tissue and selection by an adherent step. ADSCs display many common features with mesenchymal stem cells derived from bone marrow, including paracrine activity, but with some specific features, among which a greater angiogenic potential. This potential is now investigating at clinical level to treat critical ischemic hindlimb by autologous cells. Other potentials are also investigated and the treatment of fistula associated or not with Crohn's disease is reaching now phase III level. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：124 / 128
页数：5
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