Polymers in gene therapy: Antisense delivery systems

被引：0
作者：
Israel, ZH [1 ]
Domb, AJ
机构：
[1] Hadassah Univ Hosp, Dept Neurosurg, IL-91120 Jerusalem, Israel
[2] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, Dept Pharmaceut Chem, IL-91120 Jerusalem, Israel
来源：
POLYMERS FOR ADVANCED TECHNOLOGIES | 1998年 / 9卷 / 10-11期
关键词：
antisense oligonucleotides; polymer; gene therapy; delivery systems;
D O I：
10.1002/(SICI)1099-1581(1998100)9:10/11<799::AID-PAT807>3.0.CO;2-N
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Antisense aligonucleotides can down-regulate or specifically turn off individual genes and have therefore received much attention in the era of gene therapy. while effective in vitro, delivery in vivo has been problematic. This review focusses on the progress of polymeric, non-viral methods of antisense delivery and also describes some of the exciting potential clinical applications of this technology. (C) 1998 John Wiley & Sons, Ltd.
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收藏
页码：799 / 805
页数：7
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