Asymmetric synthesis of α,α-disubstituted α-amino alcohol derivatives

被引：6

作者：

Iio, Yukiko ^{[1
]}

Yamaoka, Makoto ^{[2
]}

Jin, Masayoshi ^{[2
]}

Nakamura, Yoshitaka ^{[2
]}

Nishi, Takahide ^{[1
]}

机构：

[1] Lead Discovery & Optimizat Res Labs 1, Shinagawa Ku, Tokyo 1408710, Japan

[2] Daiichi Sankyo Co Ltd, Proc Technol Res Labs, Hiratsuka, Kanagawa 2540014, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2011年 / 22卷 / 03期

关键词：

STEREOSELECTIVE-SYNTHESIS; CHIRAL ANALOGS; ACIDS; 2-AMINO-2-METHYL-1,3-PROPANEDIOL; IMMUNOSUPPRESSANT; FTY720; SERINE;

D O I：

10.1016/j.tetasy.2011.02.006

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Herein we report the asymmetric synthesis of alpha,alpha-disubstituted alpha-amino alcohol derivatives 22, 25 and 26, key intermediates of a novel immunomodulator, using Seebach's method. This synthetic method can be applied to the large scale synthesis of chiral sphingosine 1-phosphate-1 (S1P(1)) receptor agonists, with significant improvements to the previously reported method with regard to the reaction temperature. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：323 / 328

页数：6

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