The Role of Monocytes and Macrophages in Age-Related Macular Degeneration

被引：21

作者：

Grunin, Michelle ^{[1
]}

Hagbi-Levi, Shira ^{[1
]}

Chowers, Itay ^{[1
]}

机构：

[1] Hadassah Hebrew Univ Med Ctr, Dept Ophthalmol, IL-91120 Jerusalem, Israel

来源：

RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2014年 / 801卷

关键词：

Monocytes/macrophages; Age-related macular degeneration; Chemokine signaling; Mouse models of retinal degeneration; CHEMOKINE RECEPTOR EXPRESSION; RETINAL DEGENERATION; BLOOD MONOCYTES; BRUCHS MEMBRANE; AQUEOUS-HUMOR; ACTIVATION; CELLS; GENE; RECRUITMENT; SUBSETS;

D O I：

10.1007/978-1-4614-3209-8_26

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

White blood cells, particularly monocytes and their descendants, macrophages, have been implicated in age-related macular degeneration (AMD) pathology. In this minireview, we describe the current knowledge of monocyte and macrophage involvement in AMD. Chemokine receptors present on these cells such as CCR1, CCR2, and CX3CR1, and their roles in monocyte/macrophage recruitment to sites of injury and inflammation in the context of AMD will be reviewed. Mice models for perturbation of chemokine receptors that recapitulate some of the features of AMD are also described. The body of evidence from human and rodent studies at this point in time suggests that monocyte and macrophages may modulate the course of AMD.

引用

页码：199 / 205

页数：7

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