Desperately seeking targets

被引:2
作者
Jordan, Bertrand [1 ,2 ]
机构
[1] Aix Marseille Univ EFS CNRS, UMR ADES 7268, Espace Eth Mediterraneen, Hop Adultes Timone, F-13385 Marseille 05, France
[2] CoReBio PACA, F-13288 Marseille 09, France
来源
M S-MEDECINE SCIENCES | 2015年 / 31卷 / 02期
关键词
CANCER;
D O I
10.1051/medsci/20153102020
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In clinical oncology, obtaining sequence data from tumour samples has become practical in terms of logistics, turnover time and costs. The major issue now is the interpretation of this sequence to define actionable targets, i.e. genome changes that are involved in tumorogenesis and that predict the efficacy of existing and available targeted treatments. This is the focus of major efforts from public clinical centres and from companies that see it as a promising commercial activity.
引用
收藏
页码:214 / 217
页数:4
相关论文
共 8 条
[1]   Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER) [J].
Andre, Fabrice ;
Bachelot, Thomas ;
Commo, Frederic ;
Campone, Mario ;
Arnedos, Monica ;
Dieras, Veronique ;
Lacroix-Triki, Magali ;
Lacroix, Ludovic ;
Cohen, Pascale ;
Gentien, David ;
Adelaide, Jose ;
Dalenc, Florence ;
Goncalves, Anthony ;
Levy, Christelle ;
Ferrero, Jean-Marc ;
Bonneterre, Jacques ;
Lefeuvre, Claudia ;
Jimenez, Marta ;
Filleron, Thomas ;
Bonnefoi, Herve .
LANCET ONCOLOGY, 2014, 15 (03) :267-274
[2]   Development of the clinical next-generation sequencing industry in a shifting policy climate [J].
Curnutte, Margaret A. ;
Frumovitz, Karen L. ;
Bollinger, Juli M. ;
McGuire, Amy L. ;
Kaufman, David J. .
NATURE BIOTECHNOLOGY, 2014, 32 (10) :980-982
[3]   Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing [J].
Frampton, Garrett M. ;
Fichtenholtz, Alex ;
Otto, Geoff A. ;
Wang, Kai ;
Downing, Sean R. ;
He, Jie ;
Schnall-Levin, Michael ;
White, Jared ;
Sanford, Eric M. ;
An, Peter ;
Sun, James ;
Juhn, Frank ;
Brennan, Kristina ;
Iwanik, Kiel ;
Maillet, Ashley ;
Buell, Jamie ;
White, Emily ;
Zhao, Mandy ;
Balasubramanian, Sohail ;
Terzic, Selmira ;
Richards, Tina ;
Banning, Vera ;
Garcia, Lazaro ;
Mahoney, Kristen ;
Zwirko, Zac ;
Donahue, Amy ;
Beltran, Himisha ;
Mosquera, Juan Miguel ;
Rubin, Mark A. ;
Dogan, Snjezana ;
Hedvat, Cyrus V. ;
Berger, Michael F. ;
Pusztai, Lajos ;
Lechner, Matthias ;
Boshoff, Chris ;
Jarosz, Mirna ;
Vietz, Christine ;
Parker, Alex ;
Miller, Vincent A. ;
Ross, Jeffrey S. ;
Curran, John ;
Cronin, Maureen T. ;
Stephens, Philip J. ;
Lipson, Doron ;
Yelensky, Roman .
NATURE BIOTECHNOLOGY, 2013, 31 (11) :1023-+
[4]  
Illumina Morrison C., 2014, NAT BIOTECHNOL, V32, P1073
[5]   Chronicles genomics - The clinical benefits of the new generation sequencing [J].
Jordan, Bertrand .
M S-MEDECINE SCIENCES, 2014, 30 (05) :589-593
[6]   Molecular Tumor Board: The University of California San Diego Moores Cancer Center Experience [J].
Schwaederle, Maria ;
Parker, Barbara A. ;
Schwab, Richard B. ;
Fanta, Paul T. ;
Boles, Sarah G. ;
Daniels, Gregory A. ;
Bazhenova, Lyudmila A. ;
Subramanian, Rupa ;
Coutinho, Alice C. ;
Ojeda-Fournier, Haydee ;
Datnow, Brian ;
Webster, Nicholas J. ;
Lippman, Scott M. ;
Kurzrock, Razelle .
ONCOLOGIST, 2014, 19 (06) :631-636
[7]   Apple moves on health, drug developers shift into smart gear [J].
Sheridan, Cormac .
NATURE BIOTECHNOLOGY, 2014, 32 (10) :965-966
[8]  
Tansey B, DATA CO CARVE OUT NI