One-pot multi-component synthesis of novel ethyl-2-(3-((2-(4-(4-aryl)thiazol-2-yl)hydrazono)methyl)-4-hydroxy/isobutoxyphenyl)-4-methylthiazole-5-carboxylate derivatives and evaluation of their in vitro antimicrobial activity

被引：7
|
作者：
Deshineni, Rajitha [1 ]
Velpula, Ravibabu [2 ]
Koppu, Suneetha [1 ]
Pilli, Jyothi [1 ]
Chellamella, Gyanakumari [1 ]
机构：
[1] Osmania Univ, Dept Chem, Hyderabad 500007, Telangana, India
[2] Natl Inst Technol, Dept Chem, Warangal, Telangana, India
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 03期
关键词：
BIOLOGICAL EVALUATION; THIAZOLE DERIVATIVES; SCHIFF-BASES; INHIBITORS; AGENTS;
D O I：
10.1002/jhet.3872
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel series of ethyl-2-(3-((2-(4-(4-aryl)thiazol-2-yl)hydrazono)methyl)-4-hydroxy/isobutoxyphenyl)-4-methylthiazole-5-carboxylate derivatives (4a-f and 5a-f) were synthesized by employing one-pot multi-component approach involving ethyl 2-(3-formyl-4-oxy/isobutoxyphenyl)-4-methylthiazole-5-carboxylate, thiosemicarbazide and various phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one/2-(2-bromoacetyl)-3H-benzo[f]chromen-3-onein ethanol in the presence of catalytic amount of acetic acid. The structures of all the synthesized compounds were confirmed with spectral analysis, ie, IR, 1H NMR, 13C NMR and mass spectrometry, and all the compounds were screened for their in vitro antimicrobial activity.
引用
收藏
页码：1361 / 1367
页数：7
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