Transcriptional adaptation of neuroblastoma cells to hypoxia

被引：23
作者：
Fredlund, Erik [1 ]
Ovenberger, Marie [1 ]
Borg, Ake [2 ]
Pahlman, Sven [1 ]
机构：
[1] Lund Univ, Univ Hosp MAS, Dept Lab Med, Div Mol Med, SE-20502 Malmo, Sweden
[2] Lund Univ, Dept Clin Sci, Div Oncol, SE-22100 Lund, Sweden
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 366卷 / 04期
关键词：
hypoxia; neuroblastoma; microarray;
D O I：
10.1016/j.bbrc.2007.12.074
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2 alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：1054 / 1060
页数：7
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