Transcriptional adaptation of neuroblastoma cells to hypoxia

被引：23

作者：

Fredlund, Erik ^{[1
]}

Ovenberger, Marie ^{[1
]}

Borg, Ake ^{[2
]}

Pahlman, Sven ^{[1
]}

机构：

[1] Lund Univ, Univ Hosp MAS, Dept Lab Med, Div Mol Med, SE-20502 Malmo, Sweden

[2] Lund Univ, Dept Clin Sci, Div Oncol, SE-22100 Lund, Sweden

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2008年 / 366卷 / 04期

关键词：

hypoxia; neuroblastoma; microarray;

D O I：

10.1016/j.bbrc.2007.12.074

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Low oxygen pressure (hypoxia) is a physiological condition that has been linked to tumor progression and increased malignancy in several cancer forms. Cells of the childhood neoplasm neuroblastoma respond to hypoxia by attaining a lower grade of differentiation, which clinically is associated with poor prognosis. Furthermore, expression of the hypoxia inducible factor-2 alpha correlates to poor outcome in neuroblastoma patients. In this report we have by microarray analysis studied transcriptional changes in seven neuroblastoma cell lines subjected to long term hypoxia. We find the gene regulatory response to be highly dependent on cell line background, however, a set of genes was coherently regulated by hypoxia and these genes are correlated to known hypoxia-induced transcriptional profiles. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1054 / 1060

页数：7

共 38 条

[1] Identification and characterization of regulator of G protein signaling 4 (RGS4) as a novel inhibitor of tubulogenesis: RGS4 inhibits mitogen-activated protein kinases and vascular endothelial growth factor signaling [J].

Albig, AR ;

Schiemann, WP .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (02) :609-625

[2] Hypoxia-induced dedifferentiation of tumor cells -: A mechanism behind heterogeneity and aggressiveness of solid tumors [J].

Axelson, H ;

Fredlund, E ;

Ovenberger, M ;

Landberg, G ;

Påhlman, S .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (4-5) :554-563

[3] Genes commonly upregulated by hypoxia in human breast cancer cells MCF-7 and MDA-MB-231 [J].

Bando, H ;

Toi, M ;

Kitada, K ;

Koike, M .

BIOMEDICINE & PHARMACOTHERAPY, 2003, 57 (08) :333-340

[4] Hypoxia converts human macrophages into triglyceride-loaded foam cells [J].

Bostrom, Pontus ;

Magnusson, Bjorn ;

Svensson, Per-Arne ;

Wiklund, Olov ;

Boren, Jan ;

Carlsson, Lena M. S. ;

Stahlman, Marcus ;

Olofsson, Sven-Olof ;

Hulten, Lillemor Mattsson .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (08) :1871-1876

[5] Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments [J].

Breitling, R ;

Armengaud, P ;

Amtmann, A ;

Herzyk, P .

FEBS LETTERS, 2004, 573 (1-3) :83-92

[6] The transcription factor DEC1 (stra13, SHARP2) is associated with the hypoxic response and high tumour grade in human breast cancers [J].

Chakrabarti, J ;

Turley, H ;

Campo, L ;

Han, C ;

Harris, AL ;

Gatter, KC ;

Fox, SB .

BRITISH JOURNAL OF CANCER, 2004, 91 (05) :954-958

[7] Gene expression programs in response to hypoxia: Cell type specificity and prognostic significance in human cancers [J].

Chi, JT ;

Wang, Z ;

Nuyten, DSA ;

Rodriguez, EH ;

Schaner, ME ;

Salim, A ;

Wang, Y ;

Kristensen, GB ;

Helland, A ;

Borresen-Dale, AL ;

Giaccia, A ;

Longaker, MT ;

Hastie, T ;

Yang, GP ;

van de Vijver, MJ ;

Brown, PO .

PLOS MEDICINE, 2006, 3 (03) :395-409

[8] Human fetal neuroblast and neuroblastoma transcriptome analysis confirms neuroblast origin and highlights neuroblastoma candidate genes [J].

De Preter, Katleen ;

Vandesompele, Jo ;

Heimann, Pierre ;

Yigit, Nurten ;

Beckman, Siv ;

Schramm, Alexander ;

Eggert, Angelika ;

Stallings, Raymond L. ;

Benoit, Yves ;

Renard, Marleen ;

De Paepe, Anne ;

Laureys, Genevieve ;

Pahlman, Sven ;

Speleman, Frank .

GENOME BIOLOGY, 2006, 7 (09)

[9] Investigating hypoxic tumor physiology through gene expression patterns [J].

Denko, NC ;

Fontana, LA ;

Hudson, KM ;

Sutphin, PD ;

Raychaudhuri, S ;

Altman, R ;

Giaccia, AJ .

ONCOGENE, 2003, 22 (37) :5907-5914

[10] E2F7, a novel E2F featuring DP-independent repression of a subset of E2F-regulated genes [J].

Di Stefano, L ;

Jensen, MR ;

Helin, K .

EMBO JOURNAL, 2003, 22 (23) :6289-6298

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