Expression and clinical significance of Caveolin-1 in prostate Cancer after transurethral surgery

被引:11
作者
Wang, Xiaoming [1 ,2 ]
Liu, Zhigui [1 ]
Yang, Zhanbin [1 ]
机构
[1] Guangxi Med Univ, Dept Urol, Affiliated Hosp 1, Nanning 530021, Peoples R China
[2] Guangxi Med Univ, Dept Urol, Affiliated Hosp 2, 166 DaXueDong Rd, Nanning 530007, Guangxi, Peoples R China
关键词
Prostate cancer; Benign prostatic hyperplasia; Caveolin-1; Immunohistochemistry; PANCREATIC-CANCER; BREAST-CANCER; LUNG-CANCER; CELL-LINES; METASTASIS; GROWTH; OVEREXPRESSION; BIOMARKERS; CARCINOMA; TUMORIGENESIS;
D O I
10.1186/s12894-018-0418-4
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
BackgroundProstate cancer is a common malignancy of the male genitourinary system that occurs worldwide. The current research aims to investigate caveolin-1 expression in prostate cancer tissue and its relationship with pathological grade, clinical pathologic staging, and preoperative prostate-specific antigen (PSA) levels.MethodsFrom January 2012 to December 2014, samples from 47 patients with prostate cancer who had received transurethral prostatic resection (TURP) and 20 patients with benign prostatic hyperplasia were collected at the First Affiliated Hospital of Guangxi Medical University. Caveolin-1 was detected by streptavidin-perosidase (SP) immunohistochemical staining in pathological tissue slices. The results were statistically analyzed for pathological grade, clinical stage, and preoperative PSA level.ResultsThe expression of caveolin-1 was significantly higher in prostate cancer samples than in benign prostatic hyperplasia samples (P<0.05), and caveolin-1 expression was significantly different among the pathological grades of poorly, moderately and well-differentiated prostate cancer (P<0.05). The difference in caveolin-1 expression was significant for different clinical stages (T1-T2 and T3-T4) of prostate cancer (P<0.05). The difference in caveolin-1 expression was not significant among samples with different preoperative PSA levels (0-10, 10-100 and>100g/L) (P>0.05).ConclusionsCaveolin-1 is closely related to the pathological grade and clinical stage of prostate cancer after transurethral surgery, and it may be a novel tumor marker for prostate cancer. The expression of caveolin-1 is not associated with preoperative serum PSA levels.
引用
收藏
页数:7
相关论文
共 32 条
[1]  
Anwar Sumadi Lukman, 2015, Asian Pac J Cancer Prev, V16, P6803
[2]   Expression Profiles and Functional Associations of Endogenous Androgen Receptor and Caveolin-1 in Prostate Cancer Cell Lines [J].
Bennett, Nigel C. ;
Hooper, John D. ;
Johnson, David W. ;
Gobe, Glenda C. .
PROSTATE, 2014, 74 (05) :478-487
[3]   Metronomic Ceramide Analogs Inhibit Angiogenesis in Pancreatic Cancer through Up-regulation of Caveolin-1 and Thrombospondin-1 and Down-regulation of Cyclin D1 [J].
Bocci, Guido ;
Fioravanti, Anna ;
Orlandi, Paola ;
Di Desidero, Teresa ;
Natale, Gianfranco ;
Fanelli, Giovanni ;
Viacava, Paolo ;
Naccarato, Antonio Giuseppe ;
Francia, Giulio ;
Danesi, Romano .
NEOPLASIA, 2012, 14 (09) :833-U195
[4]  
Dickinson James, 2016, CMAJ Open, V4, pE73, DOI 10.9778/cmajo.20140079
[5]   Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis [J].
Friedrich, Teresa ;
Richter, Birgit ;
Gaiser, Timo ;
Weiss, Christel ;
Janssen, Klaus-Peter ;
Einwaechter, Henrik ;
Schmid, Roland M. ;
Ebert, Matthias P. A. ;
Burgermeister, Elke .
CARCINOGENESIS, 2013, 34 (09) :2109-2118
[6]   Caveolae as a target to quench autoinduction of the metastatic phenotype in lung cancer [J].
Garnett, David John .
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2016, 142 (03) :611-618
[7]   A Novel FoxM1-Caveolin Signaling Pathway Promotes Pancreatic Cancer Invasion and Metastasis [J].
Huang, Chen ;
Qiu, Zhengjun ;
Wang, Liwei ;
Peng, Zhihai ;
Jia, Zhiliang ;
Logsdon, Craig D. ;
Le, Xiangdong ;
Wei, Daoyan ;
Huang, Suyun ;
Xie, Keping .
CANCER RESEARCH, 2012, 72 (03) :655-665
[8]   Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence [J].
Karam, Jose A. ;
Lotan, Yair ;
Roehrborn, Claus G. ;
Ashfaq, Raheela ;
Karakiewicz, Pierre I. ;
Shariat, Shahrokh F. .
PROSTATE, 2007, 67 (06) :614-622
[9]   Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer - Caveolin-1 (P132L) behaves in a dominant-negative manner and Caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia [J].
Lee, H ;
Park, DS ;
Razani, B ;
Russell, RG ;
Pestell, RG ;
Lisanti, MP .
AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (04) :1357-1369
[10]   Constitutive and growth factor-regulated phosphorylation of caveolin-1 occurs at the same site (Tyr-14) in vivo:: Identification of a c-Src/Cav-1/Grb7 signaling cassette [J].
Lee, H ;
Volonte, D ;
Galbiati, F ;
Iyengar, P ;
Lublin, DM ;
Bregman, DB ;
Wilson, MT ;
Campos-Gonzalez, R ;
Bouzahzah, B ;
Pestell, RG ;
Scherer, PE ;
Lisanti, MP .
MOLECULAR ENDOCRINOLOGY, 2000, 14 (11) :1750-1775