Constituents from Entada scandens with TRAIL-resistance Overcoming Activity

被引:0
作者
Ahmed, Firoj [1 ,2 ]
Toume, Kazufumi [1 ]
Ishikawa, Naoki [1 ]
Arai, Midori A. [1 ]
Sadhu, Samir K. [3 ]
Ishibashi, Masami [1 ]
机构
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, 1-8-1 Inohana, Chiba 2608675, Japan
[2] Univ Dhaka, Dept Pharmaceut Chem, Dhaka 1000, Bangladesh
[3] Khulna Univ, Pharm Discipline, Khulna 9208, Bangladesh
关键词
Entada scandens; TRAIL-resistance overcoming activity; INDUCED APOPTOSIS; SCREENING-PROGRAM; UP-REGULATION; PHASEOLOIDES; CANCER; CELLS; ENHANCEMENT; DERIVATIVES; MECHANISMS; GLYCOSIDES;
D O I
暂无
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has emerged as a promising anticancer agent because of its ability to selectively kill tumor cells. But TRAIL-resistance is a major problem of its therapy. A search for compounds for abrogating TRAIL-resistance has, thus, become an important strategy for anticancer drug discovery. In search of bioactive natural products for overcoming TRAIL-resistance, we previously reported some compounds with TRAIL-resistance overcoming activity. Bioassay guided fractionation of Entada scandens led to the isolation of four compounds (1-4). Of the isolates, compounds 1 and 3 showed moderate TRAIL-resistance overcoming activity in TRAIL-resistant human gastric adenocarcinoma (AGS) cells.
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页码:993 / 995
页数:3
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