Plasmid DNA and viral vector-based vaccines for the treatment of cancer

被引：78

作者：

Anderson, Richard J. ^{[1
]}

Schneider, Joerg ^{[1
]}

机构：

[1] Oxxon Therapeut Ltd, Oxford OX4 4GP, England

来源：

VACCINE | 2007年 / 25卷

关键词：

DNA vaccines; viral vectors; cancer vaccines;

D O I：

10.1016/j.vaccine.2007.05.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasmid DNA and viral vector-based cancer vaccines have many inherent features that make them promising cancer vaccine candidates. This review focuses on the use of plasmid DNA and viral vector vaccines to deliver tumour-specific antigens to induce a tumour-specitic immune response. Examples of different antigen delivery systems that have been tested in recent clinical trials are summarised and advantages and disadvantages of a number of delivery systems and approaches are discussed. Finally, an outlook on how plasmid DNA and viral vectors might be developed further as cancer vaccines is provided. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：B24 / B34

页数：11

共 110 条

[1] Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine [J].

Amara, RR ;

Villinger, F ;

Altman, JD ;

Lydy, SL ;

O'Neil, SP ;

Staprans, SI ;

Montefiori, DC ;

Xu, Y ;

Herndon, JG ;

Wyatt, LS ;

Candido, MA ;

Kozyr, NL ;

Earl, PL ;

Smith, JM ;

Ma, HL ;

Grimm, BD ;

Hulsey, ML ;

McClure, HM ;

McNicholl, JM ;

Moss, B ;

Robinson, HL .

VACCINE, 2002, 20 (15) :1949-1955

[2] Plasmid vectors encoding cholera toxin or the heat-labile enterotoxin from Escherichia coli are strong adjuvants for DNA vaccines [J].

Arrington, J ;

Braun, RP ;

Dong, LC ;

Fuller, DH ;

Macklin, MD ;

Umlauf, SW ;

Wagner, SJ ;

Wu, MS ;

Payne, LG ;

Haynes, JR .

JOURNAL OF VIROLOGY, 2002, 76 (09) :4536-4546

[3] Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines [J].

Barouch, DH ;

McKay, PF ;

Sumida, SM ;

Santra, S ;

Jackson, SS ;

Gorgone, DA ;

Lifton, MA ;

Chakrabarti, BK ;

Xu, L ;

Nabel, GJ ;

Letvin, NL .

JOURNAL OF VIROLOGY, 2003, 77 (16) :8729-8735

[4]

BRUN JL, 2006, 23 INT PAP C

[5] IMMUNIZATION WITH CANARYPOX VIRUS EXPRESSING RABIES GLYCOPROTEIN [J].

CADOZ, M ;

STRADY, A ;

MEIGNIER, B ;

TAYLOR, J ;

TARTAGLIA, J ;

PAOLETTI, E ;

PLOTKIN, S .

LANCET, 1992, 339 (8807) :1429-1432

[6]

Cann SAH, 2003, POSTGRAD MED J, V79, P672

[7] Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant vaccinia virus, and replication-defective adenovirus vectors expressing a human immunodeficiency virus type 1 gag gene [J].

Casimiro, DR ;

Chen, L ;

Fu, TM ;

Evans, RK ;

Caulfield, MJ ;

Davies, ME ;

Tang, A ;

Chen, MC ;

Huang, LY ;

Harris, V ;

Freed, DC ;

Wilson, KA ;

Dubey, S ;

Zhu, DM ;

Nawrocki, D ;

Mach, H ;

Troutman, R ;

Isopi, L ;

Williams, D ;

Hurni, W ;

Xu, Z ;

Smith, JG ;

Wang, S ;

Liu, X ;

Guan, LM ;

Long, R ;

Trigona, W ;

Heidecker, GJ ;

Perry, HC ;

Persaud, N ;

Toner, TJ ;

Su, Q ;

Liang, XP ;

Youil, R ;

Chastain, M ;

Bell, AJ ;

Volkin, DB ;

Emini, EA ;

Shiver, JW .

JOURNAL OF VIROLOGY, 2003, 77 (11) :6305-6313

[8] A phase I study of immunization using particle-mediated epidermal delivery of genes for gp100 and GM-CSF into uninvolved skin of melanoma patients [J].

Cassaday, Ryan D. ;

Sondel, Paul M. ;

King, David M. ;

Macklin, Michael D. ;

Gan, Jacek ;

Warner, Tom F. ;

Zuleger, Cindy L. ;

Bridges, Alan J. ;

Schalch, Heidi G. ;

Kim, Kyung Mann ;

Hank, Jacquelyn A. ;

Mahvi, David M. ;

Albertini, Mark R. .

CLINICAL CANCER RESEARCH, 2007, 13 (02) :540-549

[9] Adenovirus complexed with polyethylene glycol and cationic lipid is shielded from neutralizing antibodies in vitro [J].

Chillon, M ;

Lee, JH ;

Fasbender, A ;

Welsh, MJ .

GENE THERAPY, 1998, 5 (07) :995-1002

[10]

Conry RM, 2002, CLIN CANCER RES, V8, P2782

← 1 2 3 4 5 6 7 8 9 10 →