Two new compounds from the roots of Ilex pubescens and their cytotoxic activity

被引：6

作者：

Xiong, Huan ^{[1
]}

Zhao, Fang ^{[1
]}

Bi, Jiayi ^{[1
]}

Zhang, Yang ^{[1
]}

Zhao, Guiyun ^{[1
]}

Chen, Xue ^{[1
]}

Li, Yuncong ^{[1
]}

Yan, Rui ^{[1
]}

Zhao, Qiang ^{[1
]}

Qiao, Hua ^{[1
]}

Zhang, Guogang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, 103 Wenhua Rd, Shenyang 110016, Peoples R China

来源：

JOURNAL OF NATURAL MEDICINES | 2016年 / 70卷 / 03期

关键词：

Ilex pubescens; Lignans; Phenylethanoid; Cytotoxic activity; CHEMICAL-CONSTITUENTS; LIGNANS; NEOLIGNANS; SAPONINS;

D O I：

10.1007/s11418-016-0996-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new phenylethanoid, 1-O-beta-d-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7'R,7''S,8S,8'S,8''R)-4', 4''-dihydroxy-3,3',3'',5-tetramethoxy-7,9':7'9-diepoxy-4,8''-oxy-8,8'-sesquineolignan-7'',9''-diol (2), along with five known compounds (3-7) were isolated from the roots of Ilex pubescens. Their chemical structures were elucidated on the basis of extensive spectroscopic analysis, including UV, IR, MS, and NMR experiments. In addition, compounds 2-7 were evaluated in vitro for their cytotoxic effects on human HeLa cells; among them, compounds 2, 3, 6, and 7 showed cytotoxic activity against HeLa cells in the test.

引用

页码：673 / 678

页数：6

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