Cancer biomarkers: Current issues and future directions

被引：0
作者：
Jain, Kewal K. [1 ]
机构：
[1] Jain PharmaBiotech, CH-4057 Basel, Switzerland
来源：
CURRENT OPINION IN MOLECULAR THERAPEUTICS | 2007年 / 9卷 / 06期
关键词：
biomarker; cancer; drug development; drug discovery; methylated DNA; microRNA; molecular diagnostics; oncogenomics; oncoproteomics; personalized medicine;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Cancer biomarkers and characteristics of an ideal biomarker for cancer are discussed in this review, as well as technologies for their detection. The focus of this article is on the use of biomarkers for anticancer drug development and clinical applications, including determination of prognosis as well as monitoring of response to therapy. Types of biomarkers include methylated DNA sequences, mitochondrial DNA and microRNA. Within clinical research, oncology is expected to have the largest gains from biomarkers over the next five to ten years. Development of personalized medicine for cancer is closely linked to biomarkers, which may serve as the basis for diagnosis, drug discovery and monitoring of diseases. A major challenge in development of cancer biomarkers will be the integration of proteomics with genomics and metabolomics data and their functional interpretation in conjunction with clinical data and epidemiology.
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页码：563 / 571
页数：9
相关论文
共 42 条
[1]   Methods and biomarkers for the diagnosis and prognosis of cancer and other diseases: Towards personalized medicine [J].
Anderson, Judy E. ;
Hansen, Lise Lotte ;
Mooren, Frank C. ;
Post, Markus ;
Hug, Hubert ;
Zuse, Anne ;
Los, Marek .
DRUG RESISTANCE UPDATES, 2006, 9 (4-5) :198-210
[2]   Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity [J].
Chien, Jeremy ;
Aletti, Giovanni ;
Baldi, Alfonso ;
Catalano, Vincenzo ;
Muretto, Pietro ;
Keeney, Gary L. ;
Kalli, Kimberly R. ;
Staub, Julie ;
Ehrmann, Michael ;
Cliby, William A. ;
Lee, Yean Kit ;
Bible, Keith C. ;
Hartmann, Lynn C. ;
Kaufmann, Scott H. ;
Shridhar, Viji .
JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (07) :1994-2004
[3]   Method validation and preliminary qualification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP [J].
Cummings, J. ;
Ranson, M. ;
LaCasse, E. ;
Ganganagari, J. R. ;
St-Jean, M. ;
Jayson, G. ;
Durkin, J. ;
Dive, C. .
BRITISH JOURNAL OF CANCER, 2006, 95 (01) :42-48
[4]   Response to neoadjuvant chemotherapy in breast cancer could be predictable by measuring a novel serum apoptosis product, caspase-cleaved cytokeratin 18: A prospective pilot study [J].
Demiray, Mutlu ;
Ulukaya, Engin ;
Arslan, Murat ;
Gokgoz, Sehsuvar ;
Saraydaroglu, Ozlem ;
Ercan, Ilker ;
Evrensel, Turkkan ;
Manavoglu, Osman .
CANCER INVESTIGATION, 2006, 24 (07) :669-676
[5]   Is AMN-107 a step forward from imatinib in the treatment of chronic myeloid leukaemia? [J].
Doggrell, S .
EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2005, 14 (08) :1063-1066
[6]   The use of vascular biomarkers and imaging studies in the early clinical development of anti-tumour agents targeting angiogenesis [J].
Drevs, J. ;
Schneider, V. .
JOURNAL OF INTERNAL MEDICINE, 2006, 260 (06) :517-529
[7]   Imaging and oncologic drug development [J].
El-Deiry, Wafik S. ;
Sigman, Caroline C. ;
Kelloff, Gary J. .
JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (20) :3261-3273
[8]  
Esposito V, 2006, ANTICANCER RES, V26, P3455
[9]   MGMT methylation:: A marker of response to temozolomide in low-grade gliomas [J].
Everhard, Sibille ;
Kaloshi, Gentian ;
Criniere, Emmanuelle ;
Benouaich-Amiel, Alexandra ;
Lejeune, Julie ;
Marie, Yannick ;
Sanson, Marc ;
Kujas, Michele ;
Mokhtari, Karima ;
Hoang-Xuan, Khe ;
Delattre, Jean-Yves ;
Thillet, Joelle .
ANNALS OF NEUROLOGY, 2006, 60 (06) :740-743
[10]   Deciphering cellular states of innate tumor drug responses [J].
Graudens, E ;
Boulanger, V ;
Mollard, C ;
Mariage-Samson, R ;
Barlet, X ;
Grémy, G ;
Couillault, C ;
Lajémi, M ;
Piatier-Tonneau, D ;
Zaborski, P ;
Eveno, E ;
Auffray, C ;
Imbeaud, S .
GENOME BIOLOGY, 2006, 7 (03)
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