Self-assembling macromolecular chimeras: controlling fibrillization of a β-sheet forming peptide by polymer conjugation

被引：21

作者：

Kakwere, Hamilton ^{[1
]}

Payne, Richard J.

Jolliffe, Katrina A.

Perrier, Sebastien ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Key Ctr Polymers & Colloids, Sydney, NSW 2006, Australia

来源：

SOFT MATTER | 2011年 / 7卷 / 08期

关键词：

HYBRID BLOCK-COPOLYMERS; POLY(ETHYLENE GLYCOL); STRATEGIES; DENDRIMERS;

D O I：

10.1039/c0sm01237h

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Water soluble poly(hydroxyethyl acrylate) [P(HEA)] polymers were successfully conjugated to an azide functionalized beta-sheet forming peptide (P-11-2) to form macromolecular chimeras using Cu(I) catalyzed azide-alkyne cycloaddition ('click') chemistry. We found that the beta-sheet formation and hence fibrillization tendency of P-11-2 was severely diminished by P(HEA) conjugation. Moreover chimeras were observed to inhibit fibrillization when added to a pure b-sheet forming peptide.

引用

页码：3754 / 3757

页数：4

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