Synthesis of substituted indole derivatives as a new class of antimalarial agents

被引：116

作者：

Agarwal, A

Srivastava, K

Puri, SK

Chauhan, PMS ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Parasitol, Lucknow 226001, Uttar Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 12期

关键词：

dihydrofolate reductase; antimalarial; pyrimidine;

D O I：

10.1016/j.bmcl.2005.04.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted indole derivatives were synthesized and evaluated for their in vitro antimalarial activity against P. falciparum. Out of the 24 compounds synthesized six compounds have shown MIC of 1 mu g/mL. These compounds are in vitro several folds more active than pyrimethamine. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3133 / 3136

页数：4

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