Synthesis of Novel 1,2,4-Triazolyl Coumarin Derivatives as Potential Anticancer Agents

被引：18

作者：

Al-Wahaibi, Lamya H. ^{[1
]}

Abu-Melha, Hanaa M. ^{[1
]}

Ibrahim, Diaa A. ^{[2
,3
]}

机构：

[1] Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Chem, Riyadh 11671, Saudi Arabia

[2] Jazan Univ, Dept Chem, Fac Sci, Jazan, Saudi Arabia

[3] Natl Org Drug Control & Res, Cairo, Egypt

来源：

JOURNAL OF CHEMISTRY | 2018年 / 2018卷

关键词：

CYTOTOXICITY; ANTIOXIDANT; DESIGN;

D O I：

10.1155/2018/5201374

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel coumarin derivatives carrying 1,2,4-triazole or 1,2,4-triazolo [3,4-b] [1,3,4]thiadiazole moieties were prepared and evaluated in vitro as anticancer in the human colon cancer (HCT116) cell line. The derivatives 4c and 8c exhibited marked anticancer activity with IC50 values 4.363 and 2.656 mu M, respectively. The molecular docking studies suggested possible interaction with tyrosine kinases (CDK2).

引用

页数：8

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