Genes, nitric oxide and malaria in African children

被引：24
作者：
Clark, IA [1 ]
Rockett, KA
Burgner, D
机构：
[1] Australian Natl Univ, Sch Biochem & Mol Biol, Canberra, ACT 0200, Australia
[2] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[3] Univ Western Australia, Princess Margaret Hosp Children, Sch Paediat & Child Hlth, Perth, WA 6001, Australia
来源：
TRENDS IN PARASITOLOGY | 2003年 / 19卷 / 08期
关键词：
D O I：
10.1016/S1471-4922(03)00147-8
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The unresolved and complex relationship between nitric oxide and falciparum malaria is reflected in recent genetic and immunohistochemical studies in African children. Different genetic associations, perhaps geographically distinctive, are seen between genetic variants of the inducible nitric oxide gene and various disease manifestations in African populations. The picture might not be complete without considering the emerging roles of carbon monoxide, another endogenous gaseous mediator with similar effects to those of nitric oxide. Only when genetic comparisons from across tropical Africa are examined, in conjunction with the newly recognized complexities in the events of systemic inflammation, will this relationship be understood.
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收藏
页码：335 / 337
页数：3
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